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- W1975591797 abstract "Two new allelic exon-2 HLA-DRB sequences have been identified by using universal and also specific DRB primers. They may correspond to a previously unidentified DRB gene (DRBσ) and define a new supratypic group (“DRw54”) which includes DR1, DR“Br”, DR2 and DRw10 bearing HLA haplotypes. This is probably the last HLA-DRB gene to be described in the standard DR haplotypes on the bases of the number of TaqI RFLPs obtained. Sequence comparison with their respective DP and DQ sequences shows that DRBσ is unequivocally placed within the DRB family and also a constructed “neighbouring homology tree” indicates that DRBσ gene is probably the eldest in the DRB family, thus the first to diverge from the ancestral DRB gene. An hypothetically deduced DRBσ β1 protein domain was found to be quite different from the corresponding DRB1, DRB3, DRB4 and DRB5 products, since residues 40–55 would bear a longer α-helical conformation and would also exist a loss of both the extended conformation at residues 50–54 and the α-helix at residues 64–71. Thus, the putative DRBσ protein would be remarkably different to other DRB ones. Also, a DRBσ partial transcript (exon-2) has been obtained by PCR of cDNA by using specific DRBσ oligonucleotides, but a specific Northern blot hybridization has not been achieved." @default.
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- W1975591797 date "1991-04-01" @default.
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- W1975591797 title "Exon-2 nucleotide sequences, polymorphism and haplotype distribution of a new HLA-DRB gene: HLA-DRBσ" @default.
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- W1975591797 doi "https://doi.org/10.1016/0161-5890(91)90168-j" @default.
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