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- W1975647462 abstract "In Brief Background Previous studies have demonstrated that leptin is an angiogenic factor, and an increase in intravitreous leptin concentrations in diabetic patients with proliferative diabetic retinopathy (PDR) has also been described. The aim of the present study was to investigate the source of intravitreal leptin and to determine whether it is related to PDR activity. Methods Serum and vitreous fluid samples were obtained simultaneously at the time of vitreoretinal surgery from 25 patients with PDR and 32 nondiabetic patients with nonproliferative ocular diseases (controls). Both groups were matched by age, sex, and body mass index. Leptin levels were determined by ELISA. Results We did not observe any significant differences in vitreal levels of leptin between diabetic patients with PDR and controls (4.22 [2.6–9.7] versus 3.49 [1.9–9.7] ng/mL; P = not significant). Leptin concentrations were lower in vitreous fluid than in serum samples from diabetic patients with PDR (P < 0.001) and controls (P < 0.001). A direct correlation between serum and vitreous leptin concentrations was detected in diabetic patients with PDR (r = 0.60; P = 0.01) and controls (r = 0.51; P = 0.01). Finally, we did not observe any relationship between intravitreous leptin levels and PDR activity. Conclusions The intraocular production of leptin is not critically involved in the etiopathogenesis of PDR. In addition, our results suggest that serum diffusion is a relevant source of leptin in vitreous fluid. This careful case control study shows that IV leptin levels in patients with diabetes and proliferative diabetic retinopathy are similar to those in patients who do not have diabetes. In addition, no relationship between IV leptin levels and proliferative diabetic retinopathic activity was observed. These results suggest that the intraocular production of leptin is not a relevant factor in the etiopathogenesis of proliferative diabetic retinopathy." @default.
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- W1975647462 date "2004-02-01" @default.
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- W1975647462 title "INTRAVITREOUS LEPTIN CONCENTRATIONS IN PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHY" @default.
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- W1975647462 doi "https://doi.org/10.1097/00006982-200402000-00005" @default.
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