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- W1975650297 abstract "A marine sponge Petrosia similis afforded two compounds which belongs to bis-quinolizidine alkaloids namely, petrosin (1) and petrosin-A (2), respectively. Petrosin (1) and petrosin-A (2) showed anti-HIV inhibition with IC(50) values of 41.3 and 52.9 microm respectively. MAGI cell assays indicated that the compounds inhibited early steps of HIV replication. In extracellular HIV-1 Reverse Transcriptase inhibition assay petrosin and petrosin-A inhibited HIV-1 RT at 10.6 and 14.8 microm. This is the first report of petroisns with anti-HIV activity." @default.
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- W1975650297 date "2003-01-01" @default.
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- W1975650297 title "Anti-HIV Active Petrosins from the Marine Sponge Petrosia similis1)" @default.
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- W1975650297 doi "https://doi.org/10.1248/bpb.26.1498" @default.
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