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• W1975657711 abstract "The effective management of pain is an important component of recovery in the postsurgical and other acute pain settings, 1 Apfelbaum J.L. Chen C. Mehta S.S. et al. Postoperative pain experience: Results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003; 97: 534 Crossref PubMed Scopus (1442) Google Scholar , 2 Holder K.A. Dougherty T.B. Porche V.H. et al. Postoperative pain management. Int Anesthesiol Clin. 1998; 36: 71 Crossref PubMed Scopus (13) Google Scholar because both suboptimal therapy and side effects can delay a patient’s recovery and ability to leave the treatment setting. 3 Karani R. Meier D.E. Systemic pharmacologic postoperative pain management in the geriatric orthopaedic patient. Clin Orthop Relat Res. 2004; 424: 26 Crossref Scopus (34) Google Scholar , 4 Skinner H.B. Multimodal acute pain management. Am J Orthop. 2004; 33: 5 Crossref PubMed Google Scholar Combination analgesics containing opioids and acetaminophen are commonly used to treat postsurgical and other forms of acute pain. However, oral opioids undergo extensive first-pass metabolism, leading to unpredictable and relatively short response, and can cause nausea, vomiting, and central nervous system side effects 5 Polomano R.C. Heffner S.M. Reck D.L. et al. Evidence for opioid variability Part 2: Psychosocial influences. Semin Perioper Nurs. 2001; 10: 159 PubMed Google Scholar , 6 Polomano R.C. Gelnett C.M. Heffner S.M. et al. Evidence for opioid variability Part 1: A biological perspective. Semin Perioper Nurs. 2001; 10: 3 PubMed Google Scholar , 7 Suri A. Estes K.S. Geisslinger G. et al. Pharmacokinetic-pharmacodynamic relationships for analgesics. Int J Clin Pharmacol Ther. 1997; 35: 307 PubMed Google Scholar , 8 Mogil J.S. The genetic mediation of individual differences in sensitivity to pain and its inhibition. Proc Natl Acad Sci USA. 1999; 96: 7744 Crossref PubMed Scopus (376) Google Scholar that can be additive to those of surgical anesthesia, further delaying recovery and discharge. 9 Ogilvy A.J. Smith G. The gastrointestinal tract after anaesthesia. Eur J Anaesthesiol Suppl. 1995; 10: 35 PubMed Google Scholar Nonsteroidal anti-inflammatory drugs (NSAIDs) are another option in acute pain settings, but these may prolong bleeding time and may be associated with gastrointestinal side effects, especially with prolonged use. 10 Moote C. Efficacy of nonsteroidal anti-inflammatory drugs in the management of postoperative pain. Drugs. 1992; 44: 14 Crossref PubMed Scopus (134) Google Scholar , 11 McKenna R. Abnormal coagulation in the postoperative period contributing to excessive bleeding. Med Clin North Am. 2001; 85: 1277 Abstract Full Text Full Text PDF PubMed Scopus (32) Google Scholar , 12 Hernandez-Diaz S. Garcia-Rodriguez L.A. Epidemiologic assessment of the safety of conventional nonsteroidal anti-inflammatory drugs. Am J Med. 2001; Suppl 3A: 20S Abstract Full Text Full Text PDF Google Scholar Combinations of opioids and NSAIDs or simple analgesics, such as acetaminophen, offer added efficacy but potentially greater risk of side effects." @default.
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• W1975657711 date "2007-08-01" @default.
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• W1975657711 title "A Double-Blind Randomized Controlled Trial of Rofecoxib and Multidose Oxycodone/Acetaminophen in Dental Impaction Pain" @default.
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