Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975673923> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1975673923 endingPage "222" @default.
- W1975673923 startingPage "221" @default.
- W1975673923 abstract "The effect of p53 protein expression and MIB-1 proliferative activity on survival and chemotherapeutic response in patients with lymph node (LN)-positive transitional cell carcinoma (TCC) of the urinary bladder remains unclear. The objective of this study was to assess the ability of these markers to predict disease-associated outcomes and response to chemotherapy in a cohort of patients with LN-positive TCC. The authors examined the expression of p53 and MIB-1 in the LN metastases from 139 patients who underwent cystectomy for TCC at their institution. P53 and MIB-1 nuclear staining were quantified using an image-analysis system. Cox proportional hazards regression models were used to test associations of these markers with death from TCC, distant metastases, and local recurrence for all patients and in the subset of patients who were treated with adjuvant chemotherapy. The median p53 and MIB-1 indices were 45.2% and 30.3%, respectively. The median follow-up was 4.5 years (range, 0.1–10 years). There were no statistically significant associations noted between the p53 and MIB-1 indices and the outcomes studied. When the analysis was limited to patients who were treated with adjuvant chemotherapy (n = 37 patients), the p53 index was found to have no prognostic value; however, there was a significant association between MIB-1 and distant metastases (P = 0.049). When disease-specific survival rates were stratified according to p53 index and chemotherapy, patients exhibited a response to chemotherapy regardless of p53 index. p53 and MIB-1 were not found to be associated significantly with disease-related outcomes in patients with LN-positive TCC. Adjuvant chemotherapy appeared to be effective regardless of p53 status. MIB-1 may prove useful in predicting response to chemotherapy." @default.
- W1975673923 created "2016-06-24" @default.
- W1975673923 creator A5076525924 @default.
- W1975673923 date "2005-05-01" @default.
- W1975673923 modified "2023-09-30" @default.
- W1975673923 title "Prognostic value of p53 and MIB-1 in transitional cell carcinoma of the urinary bladder with regional lymph node involvement" @default.
- W1975673923 doi "https://doi.org/10.1016/j.urolonc.2005.03.015" @default.
- W1975673923 hasPublicationYear "2005" @default.
- W1975673923 type Work @default.
- W1975673923 sameAs 1975673923 @default.
- W1975673923 citedByCount "0" @default.
- W1975673923 crossrefType "journal-article" @default.
- W1975673923 hasAuthorship W1975673923A5076525924 @default.
- W1975673923 hasConcept C121608353 @default.
- W1975673923 hasConcept C126322002 @default.
- W1975673923 hasConcept C126894567 @default.
- W1975673923 hasConcept C143998085 @default.
- W1975673923 hasConcept C146357865 @default.
- W1975673923 hasConcept C151730666 @default.
- W1975673923 hasConcept C2775910329 @default.
- W1975673923 hasConcept C2776694085 @default.
- W1975673923 hasConcept C2777546739 @default.
- W1975673923 hasConcept C2778065480 @default.
- W1975673923 hasConcept C2779762690 @default.
- W1975673923 hasConcept C2780352672 @default.
- W1975673923 hasConcept C2780849966 @default.
- W1975673923 hasConcept C50382708 @default.
- W1975673923 hasConcept C71924100 @default.
- W1975673923 hasConcept C72563966 @default.
- W1975673923 hasConcept C86803240 @default.
- W1975673923 hasConceptScore W1975673923C121608353 @default.
- W1975673923 hasConceptScore W1975673923C126322002 @default.
- W1975673923 hasConceptScore W1975673923C126894567 @default.
- W1975673923 hasConceptScore W1975673923C143998085 @default.
- W1975673923 hasConceptScore W1975673923C146357865 @default.
- W1975673923 hasConceptScore W1975673923C151730666 @default.
- W1975673923 hasConceptScore W1975673923C2775910329 @default.
- W1975673923 hasConceptScore W1975673923C2776694085 @default.
- W1975673923 hasConceptScore W1975673923C2777546739 @default.
- W1975673923 hasConceptScore W1975673923C2778065480 @default.
- W1975673923 hasConceptScore W1975673923C2779762690 @default.
- W1975673923 hasConceptScore W1975673923C2780352672 @default.
- W1975673923 hasConceptScore W1975673923C2780849966 @default.
- W1975673923 hasConceptScore W1975673923C50382708 @default.
- W1975673923 hasConceptScore W1975673923C71924100 @default.
- W1975673923 hasConceptScore W1975673923C72563966 @default.
- W1975673923 hasConceptScore W1975673923C86803240 @default.
- W1975673923 hasIssue "3" @default.
- W1975673923 hasLocation W19756739231 @default.
- W1975673923 hasOpenAccess W1975673923 @default.
- W1975673923 hasPrimaryLocation W19756739231 @default.
- W1975673923 hasRelatedWork W2016391185 @default.
- W1975673923 hasRelatedWork W2019188631 @default.
- W1975673923 hasRelatedWork W2048292871 @default.
- W1975673923 hasRelatedWork W2106811313 @default.
- W1975673923 hasRelatedWork W2146789427 @default.
- W1975673923 hasRelatedWork W2404788961 @default.
- W1975673923 hasRelatedWork W2412429625 @default.
- W1975673923 hasRelatedWork W2460063742 @default.
- W1975673923 hasRelatedWork W3112731860 @default.
- W1975673923 hasRelatedWork W188834515 @default.
- W1975673923 hasVolume "23" @default.
- W1975673923 isParatext "false" @default.
- W1975673923 isRetracted "false" @default.
- W1975673923 magId "1975673923" @default.
- W1975673923 workType "article" @default.