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• W1975691738 abstract "The diagnosis of the antiphospholipid syndrome (APS) relies on the demonstration of either the lupus anticoagulants (LAC) by coagulation tests or anti-phospholipid (aPL) antibodies by solid-phase immuno-assays on more than one occasion [ 1 Arnout J. Antiphopholipid syndrome: diagnostic aspects of lupus anticoagulants. Throm Haemost. 2001; 86: 83-91 PubMed Google Scholar , 2 Greaves M. Cohen H. Machin S.J. Mackie I. on behalf of the Haemostasis and Thrombosis Task Force of the British Committee for Standards in HaematologyGuidelines on the investigation and management of the antiphospholipid syndrome. Br J Haematol. 2000; 109: 704-715 Crossref PubMed Scopus (337) Google Scholar ]. The presence of aPL antibodies is considered as an important acquired risk factor for thrombo-embolic events [ [3] de Groot P.G. Lutters B. Derksen R.H.W.M. Lisman T. Meijers J.C.M. Rosendaal F.R. Lupus anticoagulants and the risk of a first episode of deep venous thrombosis. J Thromb Haemost. 2005; 3: 1993-1997 Crossref PubMed Scopus (166) Google Scholar ]. An overview of clinical studies indicated that the presence of LAC correlates better with thromboembolic complications than the presence of anticardiolipin (aCL) antibodies [ [4] Galli M. Luciani D. Bertolini G. Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood. 2003; 101: 1827-1832 Crossref PubMed Scopus (814) Google Scholar ]. Besides, several reports show that the β2-glycoprotein I (β2GPI) antibodies identify LAC positive patients at risk for thrombosis [ 3 de Groot P.G. Lutters B. Derksen R.H.W.M. Lisman T. Meijers J.C.M. Rosendaal F.R. Lupus anticoagulants and the risk of a first episode of deep venous thrombosis. J Thromb Haemost. 2005; 3: 1993-1997 Crossref PubMed Scopus (166) Google Scholar , 5 Galli M. Luciani D. Bertolini G. Barbui T. Anti-β2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphopholipid syndrome. Blood. 2003; 102: 2717-2723 Crossref PubMed Scopus (379) Google Scholar , 6 de Laat B. Derksen R.H.W.M. Urbanus R.T. Roest M. de Groot P.G. β2 –glycoprotein I- dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome. Blood. 2004; 104: 3598-3602 Crossref PubMed Scopus (197) Google Scholar , 7 Zoghlami-Rintelen C. Vormittag R. Sailor T. Lehr S. Quehenberger P. Rumpold H. et al. The presence of IgG antibodies against beta-2-glycoprotein I predicts the risk of thrombosis in patients with lupus anticoagulant. J Thromb Haemost. 2005; 3: 1160-1165 Crossref PubMed Scopus (81) Google Scholar , 8 de Laat B. Derksen R.H.W.M. Urbanus R.T. de Groot P.G. IgG antibodies that recognize epitope Gly40-Arg43 in domain I of β2 –glycoprotein I cause LAC, and their presence correlates strongly with thrombosis. Blood. 2005; 105: 1540-1545 Crossref PubMed Scopus (330) Google Scholar , 9 Forastiero R. Martinuzzo M. Pombo G. Puente D. Rossi A. Celebrin L. et al. A prospective study of antibodies to β2-glycoprotein I and prothrombine, and risk of thrombosis. J Thromb Haemost. 2005; 3: 1231-1238 Crossref PubMed Scopus (153) Google Scholar ]." @default.
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• W1975691738 date "2008-12-01" @default.
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• W1975691738 title "Evaluation of a new commercial dilute prothrombin time in the diagnosis of Lupus Anticoagulants" @default.
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• W1975691738 doi "https://doi.org/10.1016/j.thromres.2008.04.005" @default.
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