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- W1975697981 abstract "The evaluation of a sulfonamide inhibitor of the p53−mdm2 interaction is presented. The compound was identified using 3D database searching techniques based on a computationally derived pharmacophore model of mdm2 binding. It inhibits the physical interaction of recombinant p53 and mdm2 in vitro and increases p53-dependent transcription in an mdm2-overexpressing cell line." @default.
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- W1975697981 date "2004-07-21" @default.
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- W1975697981 title "A Nonpeptidic Sulfonamide Inhibits the p53−mdm2 Interaction and Activates p53-Dependent Transcription in mdm2-Overexpressing Cells" @default.
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- W1975697981 doi "https://doi.org/10.1021/jm034182u" @default.
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