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- W1975698977 abstract "Although multiple myeloma (MM) remains an incurable disease, the advent of novel treatment paradigms has improved survival outcomes in the past two decades. This includes widespread use of high-dose chemotherapy with autologous stem cell transplantation (HDT–ASCT) and the development of the novel agents thalidomide, lenalidomide and bortezomib. The efficacy and tolerability of these novel agents have allowed for the exploration of continuous therapy approaches. Maintenance therapy after HDT–ASCT, for example, may help prolong progression-free survival by providing sustained control of residual disease. Trials are also under way to evaluate lenalidomide in patients with high-risk smoldering MM, with the aim of delaying progression to symptomatic MM. Other research is focusing on improving HDT–ASCT protocols and integrating novel agents, such as bortezomib, as an induction or consolidation therapy. Despite these advances, more effective strategies are needed, particularly for the management of older, less fit patients who are ineligible for HDT–ASCT. Preliminary results on the use of lenalidomide maintenance therapy in elderly patients are encouraging. Taken together, these observations indicate that in this era of novel agents, optimal treatment of MM requires a long-term perspective that focuses on providing sustained disease control while maintaining quality of life." @default.
- W1975698977 created "2016-06-24" @default.
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- W1975698977 date "2013-05-01" @default.
- W1975698977 modified "2023-09-30" @default.
- W1975698977 title "Challenges in multiple myeloma diagnosis and treatment" @default.
- W1975698977 cites W1801543025 @default.
- W1975698977 cites W1879920155 @default.
- W1975698977 cites W1965249739 @default.
- W1975698977 cites W1969648097 @default.
- W1975698977 cites W1970296650 @default.
- W1975698977 cites W1974983065 @default.
- W1975698977 cites W1977691688 @default.
- W1975698977 cites W1982530466 @default.
- W1975698977 cites W1983597383 @default.
- W1975698977 cites W1988715082 @default.
- W1975698977 cites W1991466811 @default.
- W1975698977 cites W1992538067 @default.
- W1975698977 cites W1998735674 @default.
- W1975698977 cites W2009802594 @default.
- W1975698977 cites W2014073139 @default.
- W1975698977 cites W2015003025 @default.
- W1975698977 cites W2019336481 @default.
- W1975698977 cites W2021954218 @default.
- W1975698977 cites W2026716861 @default.
- W1975698977 cites W2027160261 @default.
- W1975698977 cites W2029006246 @default.
- W1975698977 cites W2032640560 @default.
- W1975698977 cites W2033024649 @default.
- W1975698977 cites W2043396394 @default.
- W1975698977 cites W2049883423 @default.
- W1975698977 cites W2055338149 @default.
- W1975698977 cites W2056955741 @default.
- W1975698977 cites W2064601405 @default.
- W1975698977 cites W2065859796 @default.
- W1975698977 cites W2066295909 @default.
- W1975698977 cites W2066800926 @default.
- W1975698977 cites W2074734350 @default.
- W1975698977 cites W2085092835 @default.
- W1975698977 cites W2087843841 @default.
- W1975698977 cites W2089107230 @default.
- W1975698977 cites W2096207943 @default.
- W1975698977 cites W2101402352 @default.
- W1975698977 cites W2101576302 @default.
- W1975698977 cites W2102591890 @default.
- W1975698977 cites W2103289287 @default.
- W1975698977 cites W2104200322 @default.
- W1975698977 cites W2104210520 @default.
- W1975698977 cites W2104238785 @default.
- W1975698977 cites W2110466835 @default.
- W1975698977 cites W2110486997 @default.
- W1975698977 cites W2113020324 @default.
- W1975698977 cites W2114217833 @default.
- W1975698977 cites W2117172636 @default.
- W1975698977 cites W2119707919 @default.
- W1975698977 cites W2120474651 @default.
- W1975698977 cites W2120780398 @default.
- W1975698977 cites W2121399230 @default.
- W1975698977 cites W2123214410 @default.
- W1975698977 cites W2123927174 @default.
- W1975698977 cites W2124240218 @default.
- W1975698977 cites W2124560610 @default.
- W1975698977 cites W2125721471 @default.
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- W1975698977 cites W2128084036 @default.
- W1975698977 cites W2134902298 @default.
- W1975698977 cites W2135326558 @default.
- W1975698977 cites W2143860449 @default.
- W1975698977 cites W2146607984 @default.
- W1975698977 cites W2149388503 @default.
- W1975698977 cites W2151595053 @default.
- W1975698977 cites W2156381278 @default.
- W1975698977 cites W2160088903 @default.
- W1975698977 cites W2169336006 @default.
- W1975698977 cites W2185344664 @default.
- W1975698977 cites W2523638885 @default.
- W1975698977 cites W2542120622 @default.
- W1975698977 cites W2549632064 @default.
- W1975698977 cites W2557578501 @default.
- W1975698977 cites W2559045020 @default.
- W1975698977 cites W3145716452 @default.
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- W1975698977 doi "https://doi.org/10.1038/leusup.2013.2" @default.
- W1975698977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4851186" @default.
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