Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975699411> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1975699411 endingPage "251" @default.
- W1975699411 startingPage "243" @default.
- W1975699411 abstract "Cetrorelix (CET) is a potent luteinizing hormone—releasing hormone (LH‐RH) antagonist and is used to prevent premature ovulation in IVF (in vitro fertilization) procedures. The objective of the present study was to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the LH suppression and LH surge delay after single doses (SD) and multiple doses (MD) of CET in healthy premenopausal women without ovarian stimulation. CET was given by subcutaneous route (SD, 0.25, 0.5, or 1 mg) on cycle day 3 and as similar multiple once‐a‐day doses from cycle day 3 to day 16 in two consecutive menstrual cycles. The concentration‐time data of CET and LH were used for PK/PD modeling. A two‐compartment model described the PK of CET with median terminal half‐life estimates of 9.2 and 54.5 hours after SD and MD, respectively. An indirect‐response E max model was used to describe the LH suppression and the LH surge delay. LH suppression was linked to plasma concentrations of CET, while the delay in the LH surge was linked to the PK of CET through a hypothetical effect compartment. Since the SD regimen on day 3 did not cause significant delay, these values were used as controls in the analysis of surge delay in MD data. The IC 50 (for suppression) estimate was 0.73 ng/ml for SD, and EC 50 (surge delay) was 1.42 ng/ml for MD. The PK/PD model adequately described the LH suppression and the surge delay." @default.
- W1975699411 created "2016-06-24" @default.
- W1975699411 creator A5000991422 @default.
- W1975699411 creator A5004586023 @default.
- W1975699411 creator A5014477849 @default.
- W1975699411 creator A5044531653 @default.
- W1975699411 creator A5066445467 @default.
- W1975699411 creator A5078634243 @default.
- W1975699411 creator A5088366031 @default.
- W1975699411 date "2003-03-01" @default.
- W1975699411 modified "2023-10-14" @default.
- W1975699411 title "Pharmacokinetic/Pharmacodynamic Modeling of Luteinizing Hormone (LH) Suppression and LH Surge Delay by Cetrorelix after Single and Multiple Doses in Healthy Premenopausal Women" @default.
- W1975699411 cites W103576120 @default.
- W1975699411 cites W1966282715 @default.
- W1975699411 cites W1978986189 @default.
- W1975699411 cites W2003666961 @default.
- W1975699411 cites W2015250191 @default.
- W1975699411 cites W2028238113 @default.
- W1975699411 cites W2045966925 @default.
- W1975699411 cites W2052067518 @default.
- W1975699411 cites W2052642042 @default.
- W1975699411 cites W2077925769 @default.
- W1975699411 cites W2078380224 @default.
- W1975699411 cites W2094719820 @default.
- W1975699411 cites W2115195541 @default.
- W1975699411 cites W2121089358 @default.
- W1975699411 cites W2133484074 @default.
- W1975699411 cites W4236509568 @default.
- W1975699411 cites W4247027611 @default.
- W1975699411 doi "https://doi.org/10.1177/0091270003251377" @default.
- W1975699411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12638392" @default.
- W1975699411 hasPublicationYear "2003" @default.
- W1975699411 type Work @default.
- W1975699411 sameAs 1975699411 @default.
- W1975699411 citedByCount "25" @default.
- W1975699411 countsByYear W19756994112013 @default.
- W1975699411 countsByYear W19756994112014 @default.
- W1975699411 countsByYear W19756994112016 @default.
- W1975699411 countsByYear W19756994112017 @default.
- W1975699411 countsByYear W19756994112018 @default.
- W1975699411 countsByYear W19756994112019 @default.
- W1975699411 crossrefType "journal-article" @default.
- W1975699411 hasAuthorship W1975699411A5000991422 @default.
- W1975699411 hasAuthorship W1975699411A5004586023 @default.
- W1975699411 hasAuthorship W1975699411A5014477849 @default.
- W1975699411 hasAuthorship W1975699411A5044531653 @default.
- W1975699411 hasAuthorship W1975699411A5066445467 @default.
- W1975699411 hasAuthorship W1975699411A5078634243 @default.
- W1975699411 hasAuthorship W1975699411A5088366031 @default.
- W1975699411 hasConcept C111113717 @default.
- W1975699411 hasConcept C112705442 @default.
- W1975699411 hasConcept C126322002 @default.
- W1975699411 hasConcept C134018914 @default.
- W1975699411 hasConcept C2777702977 @default.
- W1975699411 hasConcept C2778575703 @default.
- W1975699411 hasConcept C2778782382 @default.
- W1975699411 hasConcept C2779058012 @default.
- W1975699411 hasConcept C2779279165 @default.
- W1975699411 hasConcept C71315377 @default.
- W1975699411 hasConcept C71924100 @default.
- W1975699411 hasConceptScore W1975699411C111113717 @default.
- W1975699411 hasConceptScore W1975699411C112705442 @default.
- W1975699411 hasConceptScore W1975699411C126322002 @default.
- W1975699411 hasConceptScore W1975699411C134018914 @default.
- W1975699411 hasConceptScore W1975699411C2777702977 @default.
- W1975699411 hasConceptScore W1975699411C2778575703 @default.
- W1975699411 hasConceptScore W1975699411C2778782382 @default.
- W1975699411 hasConceptScore W1975699411C2779058012 @default.
- W1975699411 hasConceptScore W1975699411C2779279165 @default.
- W1975699411 hasConceptScore W1975699411C71315377 @default.
- W1975699411 hasConceptScore W1975699411C71924100 @default.
- W1975699411 hasIssue "3" @default.
- W1975699411 hasLocation W19756994111 @default.
- W1975699411 hasLocation W19756994112 @default.
- W1975699411 hasOpenAccess W1975699411 @default.
- W1975699411 hasPrimaryLocation W19756994111 @default.
- W1975699411 hasRelatedWork W2000170411 @default.
- W1975699411 hasRelatedWork W2024649280 @default.
- W1975699411 hasRelatedWork W2063235021 @default.
- W1975699411 hasRelatedWork W2067304466 @default.
- W1975699411 hasRelatedWork W2079007929 @default.
- W1975699411 hasRelatedWork W2145229803 @default.
- W1975699411 hasRelatedWork W2163840050 @default.
- W1975699411 hasRelatedWork W2468044930 @default.
- W1975699411 hasRelatedWork W3118753040 @default.
- W1975699411 hasRelatedWork W2006611219 @default.
- W1975699411 hasVolume "43" @default.
- W1975699411 isParatext "false" @default.
- W1975699411 isRetracted "false" @default.
- W1975699411 magId "1975699411" @default.
- W1975699411 workType "article" @default.