FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975701300> ?p ?o ?g. }

• W1975701300 endingPage "331" @default.
• W1975701300 startingPage "325" @default.
• W1975701300 abstract "Early exposure to psychostimulants has been found to lead to long-lasting effects on cognitive processes. Our lab has previously reported that juvenile male rats administered methamphetamine showed improved performance in a spatial navigation task when tested in adulthood (McFadden and Matuszewich, 2007). What is not known, however, is if these effects are specific to the developing rat, or if a similar methamphetamine protocol given to adult rats would lead to an equally beneficial long-term change in spatial cognition. In the current study, male rats were given 1 daily injection of 2mg/kg methamphetamine or saline for 15 days during either preadolescence (PD20-34) or adulthood (PD70-84). Approximately 45 days after treatment, all rats then underwent 5 days of place training in the Morris water maze at a time when juvenile rats reached adulthood. Similar to previous findings, juvenile rats exposed to repeated methamphetamine displayed shorter latencies and distances to reach the platform throughout training compared to saline-treated rats. The juvenile rats treated with methamphetamine also swam shorter distances and had faster latencies to the hidden platform compared to adult methamphetamine-treated rats. There were no significant differences in rats treated in adulthood with methamphetamine compared to saline-treated rats. Likewise, there were no effects of prior methamphetamine treatment or age on matching-to-place trials or visible platform trials. Overall, the results show that repeated methamphetamine exposure can selectively improve spatial learning in adult male rats when administered during preadolescence, but does not significantly affect spatial learning when administered in adulthood. Furthermore, the current findings demonstrate the unique susceptibility of the developing brain to drugs that modulate dopaminergic activity, as well as the long-term behavioral impact of exposure at critical ages." @default.
• W1975701300 created "2016-06-24" @default.
• W1975701300 creator A5018503420 @default.
• W1975701300 creator A5077180391 @default.
• W1975701300 date "2012-01-25" @default.
• W1975701300 modified "2023-09-27" @default.
• W1975701300 title "Juvenile but not adult methamphetamine exposure improves performance in the Morris Water Maze in male rats" @default.
• W1975701300 cites W1550776377 @default.
• W1975701300 cites W1851229443 @default.
• W1975701300 cites W1965569460 @default.
• W1975701300 cites W1975371048 @default.
• W1975701300 cites W1988970335 @default.
• W1975701300 cites W1989421820 @default.
• W1975701300 cites W1991343478 @default.
• W1975701300 cites W1996885013 @default.
• W1975701300 cites W1997119200 @default.
• W1975701300 cites W1999979314 @default.
• W1975701300 cites W2001997032 @default.
• W1975701300 cites W2007357434 @default.
• W1975701300 cites W2008150752 @default.
• W1975701300 cites W2018639245 @default.
• W1975701300 cites W2019289867 @default.
• W1975701300 cites W2022548931 @default.
• W1975701300 cites W2029009210 @default.
• W1975701300 cites W2034093030 @default.
• W1975701300 cites W2037689983 @default.
• W1975701300 cites W2051315778 @default.
• W1975701300 cites W2051334169 @default.
• W1975701300 cites W2053471966 @default.
• W1975701300 cites W2062769941 @default.
• W1975701300 cites W2063298695 @default.
• W1975701300 cites W2068676696 @default.
• W1975701300 cites W2071416598 @default.
• W1975701300 cites W2080231392 @default.
• W1975701300 cites W2087282783 @default.
• W1975701300 cites W2088753284 @default.
• W1975701300 cites W2099484254 @default.
• W1975701300 cites W2109550724 @default.
• W1975701300 cites W2112169704 @default.
• W1975701300 cites W2131396712 @default.
• W1975701300 cites W2131622291 @default.
• W1975701300 cites W2148399921 @default.
• W1975701300 cites W2159953883 @default.
• W1975701300 cites W2163320407 @default.
• W1975701300 cites W4360754350 @default.
• W1975701300 doi "https://doi.org/10.1016/j.ijdevneu.2012.01.006" @default.
• W1975701300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22306373" @default.
• W1975701300 hasPublicationYear "2012" @default.
• W1975701300 type Work @default.
• W1975701300 sameAs 1975701300 @default.
• W1975701300 citedByCount "10" @default.
• W1975701300 countsByYear W19757013002013 @default.
• W1975701300 countsByYear W19757013002014 @default.
• W1975701300 countsByYear W19757013002016 @default.
• W1975701300 countsByYear W19757013002017 @default.
• W1975701300 countsByYear W19757013002018 @default.
• W1975701300 countsByYear W19757013002020 @default.
• W1975701300 countsByYear W19757013002021 @default.
• W1975701300 crossrefType "journal-article" @default.
• W1975701300 hasAuthorship W1975701300A5018503420 @default.
• W1975701300 hasAuthorship W1975701300A5077180391 @default.
• W1975701300 hasConcept C115961737 @default.
• W1975701300 hasConcept C12515866 @default.
• W1975701300 hasConcept C126322002 @default.
• W1975701300 hasConcept C134018914 @default.
• W1975701300 hasConcept C138496976 @default.
• W1975701300 hasConcept C15744967 @default.
• W1975701300 hasConcept C169760540 @default.
• W1975701300 hasConcept C193739211 @default.
• W1975701300 hasConcept C2777397205 @default.
• W1975701300 hasConcept C2780376393 @default.
• W1975701300 hasConcept C2781161787 @default.
• W1975701300 hasConcept C2985665543 @default.
• W1975701300 hasConcept C2992926266 @default.
• W1975701300 hasConcept C42407357 @default.
• W1975701300 hasConcept C44752575 @default.
• W1975701300 hasConcept C50610925 @default.
• W1975701300 hasConcept C54355233 @default.
• W1975701300 hasConcept C71924100 @default.
• W1975701300 hasConcept C86803240 @default.
• W1975701300 hasConcept C99476002 @default.
• W1975701300 hasConceptScore W1975701300C115961737 @default.
• W1975701300 hasConceptScore W1975701300C12515866 @default.
• W1975701300 hasConceptScore W1975701300C126322002 @default.
• W1975701300 hasConceptScore W1975701300C134018914 @default.
• W1975701300 hasConceptScore W1975701300C138496976 @default.
• W1975701300 hasConceptScore W1975701300C15744967 @default.
• W1975701300 hasConceptScore W1975701300C169760540 @default.
• W1975701300 hasConceptScore W1975701300C193739211 @default.
• W1975701300 hasConceptScore W1975701300C2777397205 @default.
• W1975701300 hasConceptScore W1975701300C2780376393 @default.
• W1975701300 hasConceptScore W1975701300C2781161787 @default.
• W1975701300 hasConceptScore W1975701300C2985665543 @default.
• W1975701300 hasConceptScore W1975701300C2992926266 @default.
• W1975701300 hasConceptScore W1975701300C42407357 @default.
• W1975701300 hasConceptScore W1975701300C44752575 @default.
• W1975701300 hasConceptScore W1975701300C50610925 @default.
• W1975701300 hasConceptScore W1975701300C54355233 @default.

• next