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- W1975711700 abstract "Although up to 50% of patients diagnosed with nonulcer dyspepsia (NUD) have Helicobacter pylori infection and underlying chronic gastritis, it remains controversial whether any causal relationship exists. The results of worldwide epidemiological studies have been unconvincing. No clear-cut link has been documented between H. pylori and any specific symptom profile or pathophysiological mechanism in NUD. In the randomized controlled trials, methodological weaknesses may explain in part the conflicting results, but even in the well-conducted trials controversy persists. Although meta-analyses have attempted to resolve the issue, inherent methodological difficulties with meta-analysis remain a problem. Moreover, even the methodologically sound meta-analyses have reported conflicting results. In addition, predictors of treatment response remain obscure, and there continue to be theoretical concerns about the treatment of H. pylori infection in all patients with NUD. Hence, the management of these patients is challenging, but eradication of H. pylori infection may be beneficial in a small subgroup of cases with NUD that cannot be identified before treatment." @default.
- W1975711700 created "2016-06-24" @default.
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- W1975711700 date "2002-03-01" @default.
- W1975711700 modified "2023-10-17" @default.
- W1975711700 title "<i>Helicobacter pylori</i> and nonulcer dyspepsia" @default.
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- W1975711700 doi "https://doi.org/10.1046/j.1365-2036.2002.0160s1058.x" @default.
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