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• W1975713614 abstract "Abstract Sustained ventricular tachycardia, consisting of a regular rhythm with 100 or more consecutive ectopic beats, was studied in 14 dogs anesthetized with sodium pentobarbital 4 days after occlusion of the left anterior descending coronary artery. Electrocardiograms were recorded as well as composite (epicardial) and electrode catheter (endocardial) electrograms from the area of infarction. Sustained ventricular tachycardia was induced by atrial or ventricular pacing, or both (180 to 360/min) in 3 of 21 untreated dogs and 11 of 19 dogs treated with methylprednisolone (30 mg/kg body weight, intravenously) given at the time of coronary occlusion. Sustained ventricular tachycardia with two or more QRS configurations occurred in nine dogs, and seven dogs showed both right and left bundle branch block patterns. Ventricular tachycardia was associated with continuous electrical activation in composite epicardial electrograms that bridged interectopic intervals and showed regular patterns of electrical activation that were reproducible with each cardiac cycle. Interectopic activation patterns were distinctive for each QRS pattern. In some instances portions of activation patterns for two different configurations were similar; however, the electrographic configuration immediately before the onset of the QRS complex always differed. During ventricular tachycardia, spontaneous alterations in QRS configuration were observed in two dogs and were induced by atrial or ventricular pacing in five dogs. In all cases changes in QRS configuration during sustained ventricular tachycardia were preceded by changes in diastolic activation patterns. The results suggest that sustained ventricular tachycardia is frequently associated with stable reentrant pathways through areas of critically slow conduction. In this experimental preparation, specific, orderly and reproducible patterns were seen more often than chaotic “localized fibrillation.” Different QRS configurations after changes in interectopic patterns of continuous electrical activation are consonant with changes in specific reentrant pathways through the region of slow conduction." @default.
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• W1975713614 date "1982-01-01" @default.
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• W1975713614 title "Patterns of interectopic activation recorded during pleomorphic ventricular tachycardia after myocardial infarction in the dog" @default.
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• W1975713614 doi "https://doi.org/10.1016/0002-9149(82)90277-6" @default.
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