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- W1975718897 abstract "A major challenge in developmental biology is to understand how large-scale changes in tissue structure are generated on a cellular and molecular level. Two decades of research in molecular genetics have provided insight into the mechanisms that control cell fate and patterning, but the mechanisms that regulate the mechanical forces that shape cells and tissues are not well understood. A conserved feature of tissue architecture in vertebrates and invertebrates is a body axis that is elongated from head to tail. In the embryo of the fruit fly Drosophila, this elongation is achieved through the coordinated movements of hundreds of cells along a common axis. Several molecules that are asymmetrically localized in the plane of the tissue are crucial for planar polarized force generation and junctional remodeling during axis elongation, including components of the contractile machinery and cell-cell junctions. Using quantitative imaging, we found that these asymmetries at the cellular level result in a collective behavior in which groups of cells assemble into multicellular rosette structures that form and resolve directionally (Blankenship et al., 2006). Rosettes form through a mechanical feedback loop in which an initial asymmetry in myosin II localization is selectively stabilized in regions of increased tension to produce higher-order contractile networks (Fernandez-Gonzalez et al., 2009). This positive feedback loop that is predicted to increase the number of cells engaged in contractile behavior, promoting efficient elongation. Rosette formation has since been shown to occur during epithelial elongation in vertebrates and may represent a general mechanism linking cellular asymmetry to tissue elongation. We are currently using biophysical approaches and large-scale genetic screens to identify the machinery that directs polarized cell behavior and components of the mechanotransduction pathway that is required for tension-dependent myosin dynamics during tissue elongation." @default.
- W1975718897 created "2016-06-24" @default.
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- W1975718897 date "2013-01-01" @default.
- W1975718897 modified "2023-09-30" @default.
- W1975718897 title "Shaping the Embryo: Cellular Dynamics in Development" @default.
- W1975718897 doi "https://doi.org/10.1016/j.bpj.2012.11.071" @default.
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