Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975719619> ?p ?o ?g. }
- W1975719619 endingPage "242" @default.
- W1975719619 startingPage "230" @default.
- W1975719619 abstract "Like other cancers, uveal melanomas (UM) are characterised by an uncontrolled, clonal, cellular proliferation, occurring as a result of numerous genetic, and epigenetic aberrations. Signalling pathways known to be disrupted in UM include: (1) the retinoblastoma pathway, probably as a result of cyclin D1 overexpression; p53 signalling, possibly as a consequence of MDM2 overexpression; and the P13K/AKT and mitogen-activated protein kinase/extracellular signal-related kinase pathway pathways that are disturbed as a result of PTEN and GNAQ/11 mutations, respectively. Characteristic chromosomal abnormalities are common and include 6p gain, associated with a good prognosis, as well as 1p loss, 3 loss, and 8q gain, which correlate with high mortality. These are identified by techniques such as fluorescence in situ hybridisation, comparative genomic hybridisation, microsatellite analysis, multiplex ligation-dependent probe amplification, and single-nucleotide polymorphisms. UM can also be categorised by their gene expression profiles as class 1 or class 2, the latter correlating with poor survival, as do BRCA1-associated protein-1 (BAP1) inactivating mutations. Genetic testing of UM has enhanced prognostication, especially when results are integrated with histological and clinical data. The identification of abnormal signalling pathways, genes and proteins in UM opens the way for target-based therapies, improving prospects for conserving vision and prolonging life." @default.
- W1975719619 created "2016-06-24" @default.
- W1975719619 creator A5012448755 @default.
- W1975719619 creator A5013687466 @default.
- W1975719619 creator A5031298664 @default.
- W1975719619 creator A5063363339 @default.
- W1975719619 date "2012-12-07" @default.
- W1975719619 modified "2023-10-08" @default.
- W1975719619 title "Molecular pathology of uveal melanoma" @default.
- W1975719619 cites W135866504 @default.
- W1975719619 cites W1521892020 @default.
- W1975719619 cites W1591974336 @default.
- W1975719619 cites W1596816388 @default.
- W1975719619 cites W1909400967 @default.
- W1975719619 cites W1964585811 @default.
- W1975719619 cites W1965686242 @default.
- W1975719619 cites W1965790374 @default.
- W1975719619 cites W1966606834 @default.
- W1975719619 cites W1971297468 @default.
- W1975719619 cites W1972792164 @default.
- W1975719619 cites W1973200457 @default.
- W1975719619 cites W1973843805 @default.
- W1975719619 cites W1973904343 @default.
- W1975719619 cites W1974715203 @default.
- W1975719619 cites W1975679429 @default.
- W1975719619 cites W1978376074 @default.
- W1975719619 cites W1978731309 @default.
- W1975719619 cites W1979775163 @default.
- W1975719619 cites W1982748181 @default.
- W1975719619 cites W1983440852 @default.
- W1975719619 cites W1985727076 @default.
- W1975719619 cites W1988019690 @default.
- W1975719619 cites W1988280154 @default.
- W1975719619 cites W1990597378 @default.
- W1975719619 cites W1991262919 @default.
- W1975719619 cites W1991540105 @default.
- W1975719619 cites W1993087164 @default.
- W1975719619 cites W1994793314 @default.
- W1975719619 cites W1996119746 @default.
- W1975719619 cites W1996530575 @default.
- W1975719619 cites W1996972133 @default.
- W1975719619 cites W1997975397 @default.
- W1975719619 cites W1998327757 @default.
- W1975719619 cites W2001059662 @default.
- W1975719619 cites W2002749316 @default.
- W1975719619 cites W2002820011 @default.
- W1975719619 cites W2002820066 @default.
- W1975719619 cites W2006628286 @default.
- W1975719619 cites W2007541023 @default.
- W1975719619 cites W2008954479 @default.
- W1975719619 cites W2009004396 @default.
- W1975719619 cites W2010350415 @default.
- W1975719619 cites W2010728921 @default.
- W1975719619 cites W2010732784 @default.
- W1975719619 cites W2011133384 @default.
- W1975719619 cites W2013060223 @default.
- W1975719619 cites W2013410340 @default.
- W1975719619 cites W2013578996 @default.
- W1975719619 cites W2014955306 @default.
- W1975719619 cites W2017533041 @default.
- W1975719619 cites W2018656020 @default.
- W1975719619 cites W2019432751 @default.
- W1975719619 cites W2020862957 @default.
- W1975719619 cites W2024707988 @default.
- W1975719619 cites W2024958564 @default.
- W1975719619 cites W2025488549 @default.
- W1975719619 cites W2028027318 @default.
- W1975719619 cites W2028282939 @default.
- W1975719619 cites W2028491800 @default.
- W1975719619 cites W2030106234 @default.
- W1975719619 cites W2030954888 @default.
- W1975719619 cites W2034269086 @default.
- W1975719619 cites W2037122844 @default.
- W1975719619 cites W2038307865 @default.
- W1975719619 cites W2039062929 @default.
- W1975719619 cites W2043300321 @default.
- W1975719619 cites W2043632581 @default.
- W1975719619 cites W2043968939 @default.
- W1975719619 cites W2044822003 @default.
- W1975719619 cites W2046557593 @default.
- W1975719619 cites W2049144662 @default.
- W1975719619 cites W2049866899 @default.
- W1975719619 cites W2050252843 @default.
- W1975719619 cites W2050943731 @default.
- W1975719619 cites W2051144764 @default.
- W1975719619 cites W2051221156 @default.
- W1975719619 cites W2053520756 @default.
- W1975719619 cites W2056669712 @default.
- W1975719619 cites W2057802075 @default.
- W1975719619 cites W2058901458 @default.
- W1975719619 cites W2060143945 @default.
- W1975719619 cites W2060192787 @default.
- W1975719619 cites W2063160005 @default.
- W1975719619 cites W2067950281 @default.
- W1975719619 cites W2070465958 @default.
- W1975719619 cites W2072461683 @default.
- W1975719619 cites W2072630073 @default.
- W1975719619 cites W2075131177 @default.