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- W1975721615 abstract "There are several malaria vaccine candidates at various stages of development. Many of these target blood stages of Plasmodium falciparum. The spleen is a key site for removal of parasitized red blood cells, generation of immunity and production of new red blood cells during malaria. This article describes how all of these processes are modified following infection, and suggests that until we fully understand how these processes function and are modulated by infection, appropriate malaria vaccine design and delivery will be extremely difficult to achieve. There are several malaria vaccine candidates at various stages of development. Many of these target blood stages of Plasmodium falciparum. The spleen is a key site for removal of parasitized red blood cells, generation of immunity and production of new red blood cells during malaria. This article describes how all of these processes are modified following infection, and suggests that until we fully understand how these processes function and are modulated by infection, appropriate malaria vaccine design and delivery will be extremely difficult to achieve." @default.
- W1975721615 created "2016-06-24" @default.
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- W1975721615 date "2005-02-01" @default.
- W1975721615 modified "2023-09-30" @default.
- W1975721615 title "The importance of the spleen in malaria" @default.
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- W1975721615 doi "https://doi.org/10.1016/j.pt.2004.11.008" @default.
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