Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975752974> ?p ?o ?g. }
- W1975752974 endingPage "1900" @default.
- W1975752974 startingPage "1887" @default.
- W1975752974 abstract "Systemic administration of adenoviral vectors leads to activation of innate and antigen-specific immunity. In an attempt to diminish T and B cell-specific immune responses to E1-deleted adenoviral vectors, capsid proteins were modified with various activated monomethoxypolyethylene glycols (MPEGs). The impact of this modification was studied in a murine model of liver-directed gene transfer in which an E1-deleted adenovirus expressing the lacZ gene was given intravenously. The efficiency of vector transduction of hepatocytes in vivo was not compromised by any of the polymer chemistries. PEGylation of the virus, however, diminished the activation of cytotoxic T lymphocytes and helper T cells of the type 1 subset (Th1 cells) against native viral antigens; neutralizing antibodies to native virus were also diminished. PEGylation prolonged transgene expression and allowed partial readministration with native virus or with a virus PEGylated with a heterologous chemical moiety. Apparently, modification of the capsid leads to a shift in antigenic epitopes because vector readministration was not possible when the immunizing vector had been modified by the same PEGylation chemistry used to modify the second vector. In light of these results, the concept of improving the performance of adenoviral vectors through modification of the capsid with PEG shows promise." @default.
- W1975752974 created "2016-06-24" @default.
- W1975752974 creator A5011079275 @default.
- W1975752974 creator A5044544424 @default.
- W1975752974 creator A5051344823 @default.
- W1975752974 creator A5070314915 @default.
- W1975752974 date "2002-10-10" @default.
- W1975752974 modified "2023-10-01" @default.
- W1975752974 title "PEGylation of E1-Deleted Adenovirus Vectors Allows Significant Gene Expression on Readministration to Liver" @default.
- W1975752974 cites W1490299254 @default.
- W1975752974 cites W1555210583 @default.
- W1975752974 cites W1565397798 @default.
- W1975752974 cites W1919665734 @default.
- W1975752974 cites W1929630117 @default.
- W1975752974 cites W1964914116 @default.
- W1975752974 cites W1965372133 @default.
- W1975752974 cites W1967228746 @default.
- W1975752974 cites W1968722381 @default.
- W1975752974 cites W1971025152 @default.
- W1975752974 cites W1971122340 @default.
- W1975752974 cites W1973957725 @default.
- W1975752974 cites W1974042579 @default.
- W1975752974 cites W1976585433 @default.
- W1975752974 cites W1979822854 @default.
- W1975752974 cites W1980283599 @default.
- W1975752974 cites W1982188484 @default.
- W1975752974 cites W1982999619 @default.
- W1975752974 cites W1984376606 @default.
- W1975752974 cites W1993173549 @default.
- W1975752974 cites W1998951996 @default.
- W1975752974 cites W2005059927 @default.
- W1975752974 cites W2008131441 @default.
- W1975752974 cites W2011762615 @default.
- W1975752974 cites W2015219383 @default.
- W1975752974 cites W2017614842 @default.
- W1975752974 cites W2018628417 @default.
- W1975752974 cites W2022243496 @default.
- W1975752974 cites W2022668894 @default.
- W1975752974 cites W2031937761 @default.
- W1975752974 cites W2040386532 @default.
- W1975752974 cites W2049079105 @default.
- W1975752974 cites W2063187228 @default.
- W1975752974 cites W2064744205 @default.
- W1975752974 cites W2077451750 @default.
- W1975752974 cites W2079017842 @default.
- W1975752974 cites W2087080914 @default.
- W1975752974 cites W2090864647 @default.
- W1975752974 cites W2097831531 @default.
- W1975752974 cites W2100699905 @default.
- W1975752974 cites W2105616717 @default.
- W1975752974 cites W2107021343 @default.
- W1975752974 cites W2114458218 @default.
- W1975752974 cites W2127481689 @default.
- W1975752974 cites W2131095976 @default.
- W1975752974 cites W2133753843 @default.
- W1975752974 cites W2140905192 @default.
- W1975752974 cites W2143945307 @default.
- W1975752974 cites W2151902657 @default.
- W1975752974 cites W2152851415 @default.
- W1975752974 cites W2154038583 @default.
- W1975752974 cites W2156119419 @default.
- W1975752974 cites W2170603134 @default.
- W1975752974 cites W2171021135 @default.
- W1975752974 cites W2254140844 @default.
- W1975752974 cites W2276568341 @default.
- W1975752974 cites W2322389503 @default.
- W1975752974 cites W2952015969 @default.
- W1975752974 cites W4230774644 @default.
- W1975752974 doi "https://doi.org/10.1089/104303402760372972" @default.
- W1975752974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12396620" @default.
- W1975752974 hasPublicationYear "2002" @default.
- W1975752974 type Work @default.
- W1975752974 sameAs 1975752974 @default.
- W1975752974 citedByCount "156" @default.
- W1975752974 countsByYear W19757529742012 @default.
- W1975752974 countsByYear W19757529742013 @default.
- W1975752974 countsByYear W19757529742014 @default.
- W1975752974 countsByYear W19757529742015 @default.
- W1975752974 countsByYear W19757529742016 @default.
- W1975752974 countsByYear W19757529742017 @default.
- W1975752974 countsByYear W19757529742018 @default.
- W1975752974 countsByYear W19757529742019 @default.
- W1975752974 countsByYear W19757529742020 @default.
- W1975752974 countsByYear W19757529742021 @default.
- W1975752974 countsByYear W19757529742022 @default.
- W1975752974 countsByYear W19757529742023 @default.
- W1975752974 crossrefType "journal-article" @default.
- W1975752974 hasAuthorship W1975752974A5011079275 @default.
- W1975752974 hasAuthorship W1975752974A5044544424 @default.
- W1975752974 hasAuthorship W1975752974A5051344823 @default.
- W1975752974 hasAuthorship W1975752974A5070314915 @default.
- W1975752974 hasConcept C104317684 @default.
- W1975752974 hasConcept C111599444 @default.
- W1975752974 hasConcept C147483822 @default.
- W1975752974 hasConcept C150903083 @default.
- W1975752974 hasConcept C15152581 @default.
- W1975752974 hasConcept C153911025 @default.
- W1975752974 hasConcept C154317977 @default.