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• W1975755263 abstract "Focal nodular hyperplasia (FNH) and the less frequent hepatocellular adenoma are two different benign liver tumours with a predominance in women. In FNH spontaneous rupture rarely occurs and malignant transformation is unlikely. Therefore, it is recommended that patients with FNH are observed and to operate if tumour-related symptoms develop. By contrast, patients with adenoma should have surgery because of the considerable risk of intraperitoneal haemorrhage and development of hepatocellular carcinoma. 1 Nagorney DM Benign hepatic tumors: focal nodular hyperplasia and hepatocellular adenoma. World J Surg. 1995; 19: 13-18 Crossref PubMed Scopus (141) Google Scholar , 2 Pain JA Gimson AE Williams E Howard ER Focal nodular hyperplasia of the liver: results of treatment and options in management. Gut. 1991; 32: 524-527 Crossref PubMed Scopus (134) Google Scholar , 3 Scott LD Katz AR Duke JH Cowan DF Maklad NF Oral contraceptives, pregnancy, and focal nodular hyperplasia of the liver. JAMA. 1984; 251: 1461-1463 Crossref PubMed Scopus (68) Google Scholar , 4 Weimann A Ringe B Klempnauer J et al. Benign liver tumours: differential diagnosis and indications for surgery. World J Surg. 1997; 21: 983-991 Crossref PubMed Scopus (229) Google Scholar For both tumours, an association with use of oral contraceptives has been discussed. Because of reports about tumour regression after discontinuation, there is agreement that patients with FNH should stop oral contraceptives. 1 Nagorney DM Benign hepatic tumors: focal nodular hyperplasia and hepatocellular adenoma. World J Surg. 1995; 19: 13-18 Crossref PubMed Scopus (141) Google Scholar , 2 Pain JA Gimson AE Williams E Howard ER Focal nodular hyperplasia of the liver: results of treatment and options in management. Gut. 1991; 32: 524-527 Crossref PubMed Scopus (134) Google Scholar , 3 Scott LD Katz AR Duke JH Cowan DF Maklad NF Oral contraceptives, pregnancy, and focal nodular hyperplasia of the liver. JAMA. 1984; 251: 1461-1463 Crossref PubMed Scopus (68) Google Scholar , 4 Weimann A Ringe B Klempnauer J et al. Benign liver tumours: differential diagnosis and indications for surgery. World J Surg. 1997; 21: 983-991 Crossref PubMed Scopus (229) Google Scholar , 5 Dagradi AD Mangiante GL Focal nodular hyperplasia of the liver: a single institution experience. Acta Chir Austr. 1994; 26: 109-113 Crossref Scopus (8) Google Scholar However, it is uncertain whether pregnancy should be discouraged or whether surgical treatment is required before or even during pregnancy. 3 Scott LD Katz AR Duke JH Cowan DF Maklad NF Oral contraceptives, pregnancy, and focal nodular hyperplasia of the liver. JAMA. 1984; 251: 1461-1463 Crossref PubMed Scopus (68) Google Scholar , 5 Dagradi AD Mangiante GL Focal nodular hyperplasia of the liver: a single institution experience. Acta Chir Austr. 1994; 26: 109-113 Crossref Scopus (8) Google Scholar The few case reports are conflicting. We report 10 women with FNH who became pregnant." @default.
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• W1975755263 date "1998-04-01" @default.
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• W1975755263 title "Pregnancy in women with observed focal nodular hyperplasia of the liver" @default.
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