FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975755696> ?p ?o ?g. }

• W1975755696 endingPage "416" @default.
• W1975755696 startingPage "412" @default.
• W1975755696 abstract "Summary Context Endothelial progenitor cells (EPCs) are bone marrow‐derived cells required for endothelial repair. Circulating EPC concentration is low in conditions characterized by endothelial dysfunction but their number can be increased by treatment with phosphodiesterase‐5 (PDE5) inhibitors. EPCs are also reduced in hypogonadal men and testosterone (T) treatment restores their concentration. Objective To evaluate the relationship between the effect of PDE5 inhibitors and T on EPCs, we analysed the acute effect of vardenafil on the number of EPCs in hypogonadotrophic hypogonadal (HH) patients, before and after T treatment. Design and setting A case–control study at a university andrology centre. Patients Fifteen HH subjects and 25 aged‐matched controls. Main outcome measures The number of circulating EPCs and progenitor cells (PCs) in HH patients was evaluated after acute vardenafil administration at baseline and after 6 months of T supplementation. Results At baseline, HH men had significantly lower numbers of PCs and EPCs with respect to controls and vardenafil administration had no effect on the number of these cells. After 6 months of T treatment, all HH patients were eugonadal. With respect to baseline, PCs and EPCs were significantly higher and reached the levels observed in controls. Vardenafil administration in HH men at the end of T treatment induced a significant increase in PCs and EPCs in a manner similar to that in controls. Conclusions This study showed that normal T levels are necessary to restore the responsiveness of EPCs to PDE5 inhibitors, suggesting that T positively modulates PDE5 in bone marrow." @default.
• W1975755696 created "2016-06-24" @default.
• W1975755696 creator A5006015349 @default.
• W1975755696 creator A5014371364 @default.
• W1975755696 creator A5034455687 @default.
• W1975755696 creator A5038980643 @default.
• W1975755696 creator A5041475499 @default.
• W1975755696 creator A5072833956 @default.
• W1975755696 date "2009-08-14" @default.
• W1975755696 modified "2023-10-15" @default.
• W1975755696 title "Effect of vardenafil on endothelial progenitor cells in hypogonadotrophic hypogonadal patients: role of testosterone treatment" @default.
• W1975755696 cites W1664379753 @default.
• W1975755696 cites W172650844 @default.
• W1975755696 cites W1974867624 @default.
• W1975755696 cites W1975196221 @default.
• W1975755696 cites W1976291192 @default.
• W1975755696 cites W1996468763 @default.
• W1975755696 cites W1997825003 @default.
• W1975755696 cites W2010506532 @default.
• W1975755696 cites W2015383498 @default.
• W1975755696 cites W2017954678 @default.
• W1975755696 cites W2035256910 @default.
• W1975755696 cites W2042116568 @default.
• W1975755696 cites W2046282317 @default.
• W1975755696 cites W2049035024 @default.
• W1975755696 cites W2083601587 @default.
• W1975755696 cites W2084613663 @default.
• W1975755696 cites W2102218657 @default.
• W1975755696 cites W2109494488 @default.
• W1975755696 cites W2118047070 @default.
• W1975755696 cites W2136449685 @default.
• W1975755696 cites W2139598955 @default.
• W1975755696 cites W2142041241 @default.
• W1975755696 cites W2144317169 @default.
• W1975755696 cites W2146511410 @default.
• W1975755696 cites W2153760994 @default.
• W1975755696 cites W2160377398 @default.
• W1975755696 cites W2162271058 @default.
• W1975755696 cites W2162632293 @default.
• W1975755696 cites W282832643 @default.
• W1975755696 doi "https://doi.org/10.1111/j.1365-2265.2008.03507.x" @default.
• W1975755696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19094070" @default.
• W1975755696 hasPublicationYear "2009" @default.
• W1975755696 type Work @default.
• W1975755696 sameAs 1975755696 @default.
• W1975755696 citedByCount "19" @default.
• W1975755696 countsByYear W19757556962012 @default.
• W1975755696 countsByYear W19757556962013 @default.
• W1975755696 countsByYear W19757556962015 @default.
• W1975755696 countsByYear W19757556962016 @default.
• W1975755696 countsByYear W19757556962018 @default.
• W1975755696 countsByYear W19757556962022 @default.
• W1975755696 crossrefType "journal-article" @default.
• W1975755696 hasAuthorship W1975755696A5006015349 @default.
• W1975755696 hasAuthorship W1975755696A5014371364 @default.
• W1975755696 hasAuthorship W1975755696A5034455687 @default.
• W1975755696 hasAuthorship W1975755696A5038980643 @default.
• W1975755696 hasAuthorship W1975755696A5041475499 @default.
• W1975755696 hasAuthorship W1975755696A5072833956 @default.
• W1975755696 hasConcept C126322002 @default.
• W1975755696 hasConcept C134018914 @default.
• W1975755696 hasConcept C151730666 @default.
• W1975755696 hasConcept C201750760 @default.
• W1975755696 hasConcept C2776768464 @default.
• W1975755696 hasConcept C2778822586 @default.
• W1975755696 hasConcept C2779279991 @default.
• W1975755696 hasConcept C2779343474 @default.
• W1975755696 hasConcept C2780007613 @default.
• W1975755696 hasConcept C2780152582 @default.
• W1975755696 hasConcept C2780816001 @default.
• W1975755696 hasConcept C2780972559 @default.
• W1975755696 hasConcept C28328180 @default.
• W1975755696 hasConcept C54355233 @default.
• W1975755696 hasConcept C71924100 @default.
• W1975755696 hasConcept C74534348 @default.
• W1975755696 hasConcept C86803240 @default.
• W1975755696 hasConceptScore W1975755696C126322002 @default.
• W1975755696 hasConceptScore W1975755696C134018914 @default.
• W1975755696 hasConceptScore W1975755696C151730666 @default.
• W1975755696 hasConceptScore W1975755696C201750760 @default.
• W1975755696 hasConceptScore W1975755696C2776768464 @default.
• W1975755696 hasConceptScore W1975755696C2778822586 @default.
• W1975755696 hasConceptScore W1975755696C2779279991 @default.
• W1975755696 hasConceptScore W1975755696C2779343474 @default.
• W1975755696 hasConceptScore W1975755696C2780007613 @default.
• W1975755696 hasConceptScore W1975755696C2780152582 @default.
• W1975755696 hasConceptScore W1975755696C2780816001 @default.
• W1975755696 hasConceptScore W1975755696C2780972559 @default.
• W1975755696 hasConceptScore W1975755696C28328180 @default.
• W1975755696 hasConceptScore W1975755696C54355233 @default.
• W1975755696 hasConceptScore W1975755696C71924100 @default.
• W1975755696 hasConceptScore W1975755696C74534348 @default.
• W1975755696 hasConceptScore W1975755696C86803240 @default.
• W1975755696 hasIssue "3" @default.
• W1975755696 hasLocation W19757556961 @default.
• W1975755696 hasLocation W19757556962 @default.
• W1975755696 hasOpenAccess W1975755696 @default.
• W1975755696 hasPrimaryLocation W19757556961 @default.

• next