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• W1975757097 abstract "A technique using a fully automated on-line solid phase extraction (SPE) system (Symbiosis, Spark Holland) combined with liquid chromatography (LC)-mass spectrometry (MS/MS) has been investigated for fast bioanalytical method development, method validation and sample analysis using both conventional C18 and monolithic columns. Online SPE LC-MS/MS methods were developed in the automated mode for the quantification of model compounds (propranolol and diclofenac) directly in rat plasma. Accuracy and precision using online SPE LC-MS/MS with conventional C18 and monolithic columns were in the range of 88-111% and 0.5-14%, respectively. Total analysis cycle time of 4 min per sample was demonstrated using the C18 column. Monolithic column allowed for 2 min total cycle time without compromising the quality and validation criteria of the method. Direct plasma sample injection without on-line SPE resulted in poor accuracy and precision in the range of 41-108% and 3-81%. Furthermore, the increase in back pressure resulted in column damage after the injection of only 60 samples." @default.
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• W1975757097 date "2005-07-01" @default.
• W1975757097 modified "2023-10-10" @default.
• W1975757097 title "Development and application of a new on-line SPE system combined with LC–MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma" @default.
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• W1975757097 doi "https://doi.org/10.1016/j.chroma.2005.04.056" @default.
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