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- W1975757386 abstract "The development of fully defined culture conditions for human pre-implantation development is an important priority for human assisted reproductive technology (ART) programs. We review the important events in development to the blastocyst stage, and progress which has been made to formulate defined media to support this development. The approaches used to develop protein-free defined media for animal conceptuses will likely provide the basis for generating equivalent media able to support the timely development of human conceptuses. Low implantation rates in human ART programs is a major concern. Although some of these losses are a consequence of genetic defects in the embryos, others are likely due to asynchrony between embryonic and endometrial development. The need to culture oocytes/embryos in ART programs probably contributes to the asynchrony by slowing development. The supraphysiological concentrations of ovarian steroids, a consequence of ovarian hyperstimulation, likely exacerbates the asynchrony by accelerating endometrial development." @default.
- W1975757386 created "2016-06-24" @default.
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- W1975757386 date "1999-05-01" @default.
- W1975757386 modified "2023-09-27" @default.
- W1975757386 title "Prospects for improved pregnancy outcomes by assisted reproductive technologies" @default.
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- W1975757386 doi "https://doi.org/10.1016/s1084-2756(99)80013-x" @default.
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