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- W1975786502 abstract "Abstract Eleven methasquin-resistant sublines were selected in vitro from a Chinese hamster cell line and maintained at drug concentrations of 0.01–50.0 μg/ml . Dose-response data showed that increases in resistance ranged from 6 - to 6500 -fold and that all sublines were cross-resistant to methotrexate. Dihydrofolate reductase activity was elevated 3 - to 165 -fold in the 11 methasquin-resistant lines. Relationships between drug response and enzyme activity suggested that for 6 sublines increased dihydrofolate reductase may be the primary determinant of response, whereas additional factors such as quantitative change in other tetrahydrofolate enzymes may influence resistance to antifolate in the other 5 . Karyotype analysis of conventionally stained metaphase cells revealed the presence of nonuniformly altered chromosomes. Strikingly long chromosome segments were found on 1 homologue of chromosome 2 or 4 as a consistent feature of most, but not all, of the 11 methasquin-resistant sublines. The similarity of these findings to those previously reported for methotrexate sublines and more recent results obtained by trypsin-Giemsa banding analysis provide evidence of specific chromosomal alteration associated with increased intracellular dihydrofolate reductase." @default.
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- W1975786502 date "1978-01-01" @default.
- W1975786502 modified "2023-09-23" @default.
- W1975786502 title "Biochemical and karyological properties of cells resistant to the quinazoline antifolate, methasquin" @default.
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- W1975786502 doi "https://doi.org/10.1016/0014-2964(78)90136-6" @default.
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- W1975786502 hasPublicationYear "1978" @default.
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