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- W1975804534 abstract "Kaposi's Sarcoma-associated herpesvirus encodes a homolog of the human cellular interleukin-6 that may play a formative role in many KSHV-related diseases. While the viral IL-6 can signal similarly to its human counterpart little is known about the role of vIL-6 during KSHV infection. Using homologous recombination and selection in eukaryotic cells, a KSHV isolate was purified that does not express vIL-6 as was a control recombinant that left vIL-6 intact. The two viruses establish and maintain latency to similar levels in BJAB B-cells, reactivate to similar levels in B-cells and Monkey kidney cells and have very similar KSHV gene expression patterns. BJAB cells expressing KSHV survive better than the parental BJAB cells in low serum and the vIL-6 deletion does not abrogate this growth advantage. Thus vIL-6 is not essential for establishment, maintenance, or reactivation from latency in cell culture and is not involved in the survival of infected BJAB B-cells in low serum." @default.
- W1975804534 created "2016-06-24" @default.
- W1975804534 creator A5010361359 @default.
- W1975804534 creator A5010738468 @default.
- W1975804534 date "2007-03-01" @default.
- W1975804534 modified "2023-09-25" @default.
- W1975804534 title "The KSHV viral interleukin-6 is not essential for latency or lytic replication in BJAB cells" @default.
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- W1975804534 doi "https://doi.org/10.1016/j.virol.2006.09.044" @default.
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