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- W1975806788 abstract "The heteromeric mouse ϵ2/ζ1 N-methyl-d-aspartate (NMDA) receptor was expressed in Xenopus oocytes, and its channel properties were studied using both the outside-out patch-clamp and two-microelectrode voltage-clamp techniques. In the cloned receptor channel, permeation properties of monovulent and divalent cations, and voltage-dependent block by Mg2+ were similar to those reported previously in the native NMDA receptor channels. The sequence of single-channel conductances for alkali metals was Rb+ > Cs+ ≈ K+ > Na+ > Li+, whereas the sequence of relative permeabilities was Cs+ > Rb+ > K+ ≈ Na+ > Li+. The single-channel conductances measured in isotonic Ca2+, Sr2+ and Ba2+ solutions were almost equal, and approximately one-fifth of the value in the Na+ solution, although the permeabilities for these alkaline earth cations were higher than for Na+. It is likely that Ca2+, Sr2+ and Ba2+ would enter the NMDA receptor channel more easily than Na+, but would bind to a site in the channel more tightly, the net effect being a reduced value of the current." @default.
- W1975806788 created "2016-06-24" @default.
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- W1975806788 date "2009-01-01" @default.
- W1975806788 modified "2023-10-02" @default.
- W1975806788 title "Odor-activated ionotropic olfactory receptors" @default.
- W1975806788 doi "https://doi.org/10.1016/j.neures.2009.09.1581" @default.
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