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- W1975833344 abstract "As sequencing of the draft genome of several species is completed and functional genomics studies continue to appear, an exciting new era of biomedical discovery in the environmental health sciences has come upon us. Along with it, technological advances steadily pave the way for a more complete understanding of biology and for realization that integration of molecular information into existing knowledge is essential to unraveling the complexity of biological systems. Diseases with a strong environmental etiology, such as asthma, atherosclerosis, cancer, Parkinson’s disease, and sudden cardiac death, can now be conceptualized beyond a select few mRNAs, proteins, or metabolites. And instead of thinking of one gene–one protein–one metabolite at a time, environmental disease can now be evaluated in terms of hundreds or even thousands of molecular targets. With opportunity, however, comes responsibility. The integration of genomic thinking into environmental health sciences has given rise to the new science of toxicogenomics. The term “toxicogenomics” was broadly defined in the inaugural issue of the Toxicogenomics Section in the National Institute of Environmental Health Sciences (NIEHS) journal Environmental Health Perspectives (EHP) as the science that combines genetics, genomic-scale mRNA expression (transcriptomics), protein expression (proteomics), metabolite profiling (metabolomics), and bioinformatics with toxicology to understand the role of gene–environment interactions in disease (Ramos 2003). Several other definitions have been offered, and debate continues over what toxicogenomics is and is not and whether toxicogenomics is the dawn of a new science or a fad that will someday go away. E s s a y o n Toxicogenomics" @default.
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- W1975833344 date "2005-01-01" @default.
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- W1975833344 title "A Vision That Challenges Dogma Gives Rise to a New Era in the Environmental Health Sciences" @default.
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- W1975833344 doi "https://doi.org/10.1289/ehp.7930" @default.
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