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- W1975854927 endingPage "141" @default.
- W1975854927 startingPage "127" @default.
- W1975854927 abstract "The synthesis and characterisation of R3PAu[S2CN(iPr)CH2CH2OH], for R = Ph (1), Cy (2) and Et (3)4, is reported. Compounds 1–3 are cytotoxic against the doxorubicin-resistant breast cancer cell line, MCF-7R, with 1 exhibiting greater potency and cytotoxicity than either of doxorubicin and cisplatin. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (ROS) measurements and human topoisomerase I inhibition, induction of apoptosis by 1, and necrosis by 2 and 3, are demonstrated, by both extrinsic and intrinsic pathways. Compound 1 activates the p53 gene, 2 activates only the p73 gene, whereas 3 activates both the p53 and p73 genes. Compounds 1 and 3 activate NF-κB, and each inhibits topoisomerase I." @default.
- W1975854927 created "2016-06-24" @default.
- W1975854927 creator A5000745232 @default.
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- W1975854927 creator A5019677571 @default.
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- W1975854927 creator A5061655599 @default.
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- W1975854927 creator A5077743379 @default.
- W1975854927 creator A5065511402 @default.
- W1975854927 date "2013-09-01" @default.
- W1975854927 modified "2023-10-15" @default.
- W1975854927 title "Phosphanegold(I) dithiocarbamates, R3PAu[SC(S)N(iPr)CH2CH2OH] for R = Ph, Cy and Et: Role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways" @default.
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