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• W1975858224 abstract "ObjectiveIn recent years there has been a trend towards elective single embryo transfers (ESET). Several studies have demonstrated that culturing an embryo to blastocyst stage followed by SBT increases pregnancy and delivery rates while decreasing multiple pregnancy rates. However, factors predicting LB after SBT remain undetermined. Our objective was to evaluate predictive factors for LB after SBT in women younger than 40 years old.DesignWe retrospectively analyzed all SBTs performed between January 2009 and September 2011, among women younger than 40 in our institution (n: 219). One treatment cycle per patient was analyzed.Materials and MethodsPatient characteristics included female age, body mass index, smoking, baseline antral follicle count, baseline FSH levels and IVF cycle. Treatment characteristics included stimulation protocol, total gonadotropin dose, number of stimulation days, use of recombinant LH or hMG and dose of hCG for triggering ovulation. Outcome variables included endometrial thickness, total number of oocytes, fertilization rates, numbers of blastocysts available for transfer, grade of blastocyst transferred and number of cryopreserved blastocysts. These were analyzed with univariate analysis.ResultsThe study population was divided into two groups, LB (N=81=37%) and No-LB (N=138=63%). Univariate analysis showed that the only variable that significantly affected the probability of achieving a LB was the blastocyst's quality. LB after transfers of good quality (grade 2) blastocysts was (79/199=39.7%) while LB after transfers of fair quality (grade 3) blastocyst was (2/19=10.5%, p<0.012). On sub-analysis of 203 women who received good quality blastocysts, univariate analysis did not show predictive factors for LB.ConclusionThe only predictive factor for a LB after a SBT in women of less than 40 years old is a good quality blastocyst. A good quality blastocyst seems to compensate for the age factor independent of the total number of blastocysts and other potentially predictive factors. ObjectiveIn recent years there has been a trend towards elective single embryo transfers (ESET). Several studies have demonstrated that culturing an embryo to blastocyst stage followed by SBT increases pregnancy and delivery rates while decreasing multiple pregnancy rates. However, factors predicting LB after SBT remain undetermined. Our objective was to evaluate predictive factors for LB after SBT in women younger than 40 years old. In recent years there has been a trend towards elective single embryo transfers (ESET). Several studies have demonstrated that culturing an embryo to blastocyst stage followed by SBT increases pregnancy and delivery rates while decreasing multiple pregnancy rates. However, factors predicting LB after SBT remain undetermined. Our objective was to evaluate predictive factors for LB after SBT in women younger than 40 years old. DesignWe retrospectively analyzed all SBTs performed between January 2009 and September 2011, among women younger than 40 in our institution (n: 219). One treatment cycle per patient was analyzed. We retrospectively analyzed all SBTs performed between January 2009 and September 2011, among women younger than 40 in our institution (n: 219). One treatment cycle per patient was analyzed. Materials and MethodsPatient characteristics included female age, body mass index, smoking, baseline antral follicle count, baseline FSH levels and IVF cycle. Treatment characteristics included stimulation protocol, total gonadotropin dose, number of stimulation days, use of recombinant LH or hMG and dose of hCG for triggering ovulation. Outcome variables included endometrial thickness, total number of oocytes, fertilization rates, numbers of blastocysts available for transfer, grade of blastocyst transferred and number of cryopreserved blastocysts. These were analyzed with univariate analysis. Patient characteristics included female age, body mass index, smoking, baseline antral follicle count, baseline FSH levels and IVF cycle. Treatment characteristics included stimulation protocol, total gonadotropin dose, number of stimulation days, use of recombinant LH or hMG and dose of hCG for triggering ovulation. Outcome variables included endometrial thickness, total number of oocytes, fertilization rates, numbers of blastocysts available for transfer, grade of blastocyst transferred and number of cryopreserved blastocysts. These were analyzed with univariate analysis. ResultsThe study population was divided into two groups, LB (N=81=37%) and No-LB (N=138=63%). Univariate analysis showed that the only variable that significantly affected the probability of achieving a LB was the blastocyst's quality. LB after transfers of good quality (grade 2) blastocysts was (79/199=39.7%) while LB after transfers of fair quality (grade 3) blastocyst was (2/19=10.5%, p<0.012). On sub-analysis of 203 women who received good quality blastocysts, univariate analysis did not show predictive factors for LB. The study population was divided into two groups, LB (N=81=37%) and No-LB (N=138=63%). Univariate analysis showed that the only variable that significantly affected the probability of achieving a LB was the blastocyst's quality. LB after transfers of good quality (grade 2) blastocysts was (79/199=39.7%) while LB after transfers of fair quality (grade 3) blastocyst was (2/19=10.5%, p<0.012). On sub-analysis of 203 women who received good quality blastocysts, univariate analysis did not show predictive factors for LB. ConclusionThe only predictive factor for a LB after a SBT in women of less than 40 years old is a good quality blastocyst. A good quality blastocyst seems to compensate for the age factor independent of the total number of blastocysts and other potentially predictive factors. The only predictive factor for a LB after a SBT in women of less than 40 years old is a good quality blastocyst. A good quality blastocyst seems to compensate for the age factor independent of the total number of blastocysts and other potentially predictive factors." @default.
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• W1975858224 date "2013-09-01" @default.
• W1975858224 modified "2023-10-16" @default.
• W1975858224 title "Predictive factors for live birth (LB) after single blastocyst transfer (SBT)" @default.
• W1975858224 doi "https://doi.org/10.1016/j.fertnstert.2013.07.341" @default.
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