FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975858680> ?p ?o ?g. }

• W1975858680 endingPage "778" @default.
• W1975858680 startingPage "774" @default.
• W1975858680 abstract "α-Mangostin (1) and gambogic acid (2) are natural products with potent cytotoxic activity against several human tumor cells. However, their molecular mechanisms of action remain controversial. In this work, using yeast-based assays, it was shown that both xanthones are potential inhibitors of the p53–MDM2 interaction. This activity on p53–MDM2 interaction was confirmed by a gene reporter assay in a human tumor cell. Additionally, computational docking studies supported the potential of these xanthones to bind to MDM2 and therefore act as putative MDM2 inhibitors. Altogether, this work provides a new insight concerning the molecular basis of activity for these compounds." @default.
• W1975858680 created "2016-06-24" @default.
• W1975858680 creator A5007004442 @default.
• W1975858680 creator A5008051404 @default.
• W1975858680 creator A5017062431 @default.
• W1975858680 creator A5026722432 @default.
• W1975858680 creator A5027756968 @default.
• W1975858680 creator A5057756576 @default.
• W1975858680 creator A5057925009 @default.
• W1975858680 creator A5058490092 @default.
• W1975858680 creator A5062260507 @default.
• W1975858680 date "2013-03-29" @default.
• W1975858680 modified "2023-10-17" @default.
• W1975858680 title "α-Mangostin and Gambogic Acid as Potential Inhibitors of the p53–MDM2 Interaction Revealed by a Yeast Approach" @default.
• W1975858680 cites W1496714358 @default.
• W1975858680 cites W1964884712 @default.
• W1975858680 cites W1972258341 @default.
• W1975858680 cites W1975069567 @default.
• W1975858680 cites W1975420352 @default.
• W1975858680 cites W2000588535 @default.
• W1975858680 cites W2002423563 @default.
• W1975858680 cites W2007981754 @default.
• W1975858680 cites W2024189534 @default.
• W1975858680 cites W2035796506 @default.
• W1975858680 cites W2039431907 @default.
• W1975858680 cites W2097933346 @default.
• W1975858680 cites W2112287022 @default.
• W1975858680 cites W2127582739 @default.
• W1975858680 cites W2132629607 @default.
• W1975858680 cites W2145282879 @default.
• W1975858680 cites W2147797061 @default.
• W1975858680 cites W2160310346 @default.
• W1975858680 cites W2165453779 @default.
• W1975858680 cites W2165778377 @default.
• W1975858680 cites W40735305 @default.
• W1975858680 doi "https://doi.org/10.1021/np400049j" @default.
• W1975858680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23540934" @default.
• W1975858680 hasPublicationYear "2013" @default.
• W1975858680 type Work @default.
• W1975858680 sameAs 1975858680 @default.
• W1975858680 citedByCount "35" @default.
• W1975858680 countsByYear W19758586802013 @default.
• W1975858680 countsByYear W19758586802015 @default.
• W1975858680 countsByYear W19758586802016 @default.
• W1975858680 countsByYear W19758586802017 @default.
• W1975858680 countsByYear W19758586802018 @default.
• W1975858680 countsByYear W19758586802019 @default.
• W1975858680 countsByYear W19758586802020 @default.
• W1975858680 countsByYear W19758586802021 @default.
• W1975858680 countsByYear W19758586802022 @default.
• W1975858680 countsByYear W19758586802023 @default.
• W1975858680 crossrefType "journal-article" @default.
• W1975858680 hasAuthorship W1975858680A5007004442 @default.
• W1975858680 hasAuthorship W1975858680A5008051404 @default.
• W1975858680 hasAuthorship W1975858680A5017062431 @default.
• W1975858680 hasAuthorship W1975858680A5026722432 @default.
• W1975858680 hasAuthorship W1975858680A5027756968 @default.
• W1975858680 hasAuthorship W1975858680A5057756576 @default.
• W1975858680 hasAuthorship W1975858680A5057925009 @default.
• W1975858680 hasAuthorship W1975858680A5058490092 @default.
• W1975858680 hasAuthorship W1975858680A5062260507 @default.
• W1975858680 hasConcept C104317684 @default.
• W1975858680 hasConcept C116073593 @default.
• W1975858680 hasConcept C150194340 @default.
• W1975858680 hasConcept C159110408 @default.
• W1975858680 hasConcept C161733203 @default.
• W1975858680 hasConcept C185592680 @default.
• W1975858680 hasConcept C202751555 @default.
• W1975858680 hasConcept C2775905019 @default.
• W1975858680 hasConcept C2776192174 @default.
• W1975858680 hasConcept C2779222958 @default.
• W1975858680 hasConcept C2781360439 @default.
• W1975858680 hasConcept C41685203 @default.
• W1975858680 hasConcept C55493867 @default.
• W1975858680 hasConcept C70721500 @default.
• W1975858680 hasConcept C71924100 @default.
• W1975858680 hasConcept C86803240 @default.
• W1975858680 hasConceptScore W1975858680C104317684 @default.
• W1975858680 hasConceptScore W1975858680C116073593 @default.
• W1975858680 hasConceptScore W1975858680C150194340 @default.
• W1975858680 hasConceptScore W1975858680C159110408 @default.
• W1975858680 hasConceptScore W1975858680C161733203 @default.
• W1975858680 hasConceptScore W1975858680C185592680 @default.
• W1975858680 hasConceptScore W1975858680C202751555 @default.
• W1975858680 hasConceptScore W1975858680C2775905019 @default.
• W1975858680 hasConceptScore W1975858680C2776192174 @default.
• W1975858680 hasConceptScore W1975858680C2779222958 @default.
• W1975858680 hasConceptScore W1975858680C2781360439 @default.
• W1975858680 hasConceptScore W1975858680C41685203 @default.
• W1975858680 hasConceptScore W1975858680C55493867 @default.
• W1975858680 hasConceptScore W1975858680C70721500 @default.
• W1975858680 hasConceptScore W1975858680C71924100 @default.
• W1975858680 hasConceptScore W1975858680C86803240 @default.
• W1975858680 hasIssue "4" @default.
• W1975858680 hasLocation W19758586801 @default.
• W1975858680 hasLocation W19758586802 @default.
• W1975858680 hasOpenAccess W1975858680 @default.
• W1975858680 hasPrimaryLocation W19758586801 @default.

• next