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- W1975860219 abstract "The influence of Ca+2 on the antilipolytic action of propranolol, timolol, labetalol, procaine, verapamil and papaverine, which are capable of lowering vascular tone in various ways, was investigated in isoproterenol- and ACTH-induced lipolysis in isolated rat fat cells. Under ion balance conditions, all the afore-mentioned drugs affected both lipolytic models. Labetalol, however, influenced isoproterenol-induced lipolysis to only a minor extent, whereas ACTH-induced lipolysis, considered as being Ca-dependent, was, on the other hand, affected slightly by verapamil. The absence of Ca+2 from the incubation medium reduced propranolol and timolol antilipolytic action in both isoproterenol- and ACTH-induced lipolysis. Similar action was noted with maximum papaverine, labetalol, and procaine concentrations used as isoproterenol-induced lipolysis antagonists. When Ca+2 was not present, the ACTH-inhibiting action of papaverine and labetalol was enhanced. Verapamil action seemed to be unaffected by the presence of Ca+2 in the medium. Ca+2 seems to play a major role in “non-specific” antilipolytic action of the beta-blocking drugs mentioned, although the available data do not indicate the specific points at which the cation pathways are interfered with." @default.
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- W1975860219 date "1979-10-01" @default.
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- W1975860219 title "The influence of calcium on the antilipolytic action of propranolol, timonol, labetanol, verapamil, procaine, and papaverine in rat adipocytes" @default.
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- W1975860219 doi "https://doi.org/10.1016/s0031-6989(79)80049-1" @default.
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