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- W1975870880 abstract "To examine the frequency and significance of nonspecific red-cell reactivity (NSR) on antibody (Ab) screening of obstetric inpatients. Retrospective study of obstetric inpatients with NSR found on Ab screen between 2009 and 2013. Records were reviewed for NSR resolution, preexisting or evolving red-cell Ab, transfusion reaction, or hemolytic disease of the fetus/newborn (HDFN). Evaluation of NSR by test era was done to assess the impact of an institutional change in the primary screening technique from gel-based to solid-phase red-cell adherence (SPRCA) in 2011. 5438 obstetric inpatients were studied. 290(5.3%) had at least one positive red-cell Ab screen. 88(1.6%) patients had NSR. Of these, 9(10.2%) had identifiable Abs that pre-dated NSR; 22(25%) had specific Abs identified concurrently with NSR; and 5(5.7%) had subsequent identification of a specific Ab after a previous NSR result. Overall, 40.9% had identification of another Ab at some time point. The most common identified Abs were Bg, Le(a), warm autoantibody, E, and Kell. In 43% of patients, NSR resolved during follow-up. The frequency of NSR was higher following initiation of SPRCA testing (2.22% vs 0.96%, p<0.01), but the frequency of other Ab results was similar in both testing periods (Table). 3.5% of NSR mothers had perinatal blood transfusion; no transfusion reactions were noted. Of 47 infants with maternal isolated NSR none had hour-specific bilirubin levels >95 %ile or HDFN. 8.6% of term and 41.6% of preterm infants required phototherapy. Cord blood Ab screening was performed on 27 infants; although 12 had positive Ab screening, none had positive direct Coombs testing. NSR is found in 1-2% of obstetrical patients at our institution, and the prevalence has more than doubled since the initiation of the SPRCA screening method. Although likely clinically insignificant by itself, NSR is commonly found in relation to other red-cell Abs and may precede their development, which may justify more frequent Ab screening in patients with identified NSR." @default.
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- W1975870880 date "2015-01-01" @default.
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- W1975870880 title "498: Non-specific red-cell reactivity in an obstetric population" @default.
- W1975870880 doi "https://doi.org/10.1016/j.ajog.2014.10.544" @default.
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