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- W1975883973 abstract "Objective: Antitumor effect occurs after allogeneic SCT in patients with metastatic solid cancer. However, this treatment is not as effective against liver as pulmonary and lymph node metastases. To intensify the effect of donor lymphocyte infusion (DLI) against liver metastases, we hereby describe intra-arterial (i.a.) cell injection via the hepatic artery (HA). Methods: To trace the infused cells, 3 patients with colorectal, 3 with renal and 1 with breast carcinoma, in a series of 18 SCT patients, were treated with Indium-111 (In-111) oxinate labelled lymphocytes. Four patients received the DLI via HA. They were compared with 2 patients with other metastasis and a patient without CT proven ones using In-111 DLI I.V. Results: Localisation of the i.a. In-111 DLI activity on scintigrams corresponded to sites of liver metastases on CT. In contrast, a homogenous isotope uptake over the lungs, spleen and vertebrae was found after DLI I.V. After i.a. injection, the liver to sternum ratio of radioactivity was initially high, but resembled during the following days that of the other patients with I.V. injection. Cells (CD3+, 19+, and 56+) in biopsies of liver metastases in 2 patients treated with i.a. injection were 80–100% of donor origin. Two of 4 patients treated using the i.a. DLI showed regression or stable size and number of liver metastases for 5 and 24 months, respectively. Both are alive 22 and 36 months after SCT. Two of 3 patients receiving DLI I.V. are doing well with a stable metastatic disease or still without liver metastases for 19 and 24 months after cell infusions (24 and 36 months after SCT), respectively. Conclusion: When infused via HA, In-111 labelled lymphocytes home to the liver metastases. The majority of liver metastasis infiltrating cells was of donor origin, which supports our aim to provide the DLI focally to liver metastases." @default.
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- W1975883973 date "2004-02-01" @default.
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- W1975883973 title "Indium-111 labelled donor lymphocyte infusion via hepatic artery or I.V. against liver metastases of renal and colon carcinoma after allogeneic haematopoietic stem cell transplantation" @default.
- W1975883973 doi "https://doi.org/10.1016/j.bbmt.2003.12.136" @default.
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