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- W1975887425 abstract "Renal excretory function is achieved by filtration of blood plasma; reabsorption of most of the filtered water, electrolytes, and organics; and secretion of selected solutes. The structural unit is the renal tubule (the nephron), and overall kidney function can be understood as single nephron function, scaled up in a parallel system. The earliest application of biophysical principles in understanding kidney function was glomerular filtration, rationalized according to capillary hydrostatic and oncotic forces. Tubular reabsorption and secretion is determined by the epithelial cells lining each nephron segment, and in turn, by the transport proteins within luminal and peritubular cell membranes. This review includes information developed over the past four decades, spanning several investigative eras: epithelial transport, which provided an accounting of solute fluxes along the nephron; electrophysiology and vesicle studies, which identified specific membrane transport activity; and molecular studies, which afforded the ability to clone, express, mutate, and knockout individual transporters. Mathematical models of the renal epithelia have provided a context for synthesizing biophysical representations of membrane transporter function into cellular and segmental transport. Such models can simulate experiments or pathological states and contribute to the translational dialogue between basic understanding and mechanisms of disease." @default.
- W1975887425 created "2016-06-24" @default.
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- W1975887425 date "1986-09-01" @default.
- W1975887425 modified "2023-10-15" @default.
- W1975887425 title "Erythrocyte anion transport: the kinetics of a single-site obligatory exchange system" @default.
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- W1975887425 doi "https://doi.org/10.1016/0304-4157(86)90010-9" @default.
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