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- W1975889977 abstract "Genome-wide studies of post-transcriptional mRNA regulation in model organisms indicate a post-transcriptional RNA regulon model, in which a set of functionally related genes is regulated by mRNA-binding RNAs or proteins. One well-studied post-transcriptional regulon by Puf3p functions in mitochondrial biogenesis in budding yeast. The evolution of the Puf3p regulon remains unclear because previous studies have shown functional divergence of Puf3p regulon targets among yeast, fruit fly, and humans. By analyzing evolutionary patterns of Puf3p and its targeted genes in forty-two sequenced fungi, we demonstrated that, although the Puf3p regulon is conserved among all of the studied fungi, the dedicated regulation of mitochondrial biogenesis by Puf3p emerged only in the Saccharomycotina clade. Moreover, the evolution of the Puf3p regulon was coupled with evolution of codon usage bias in down-regulating expression of genes that function in mitochondria in yeast species after genome duplication. Our results provide a scenario for how evolution like a tinker exploits pre-existing materials of a conserved post-transcriptional regulon to regulate gene expression for novel functional roles." @default.
- W1975889977 created "2016-06-24" @default.
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- W1975889977 date "2010-07-22" @default.
- W1975889977 modified "2023-09-27" @default.
- W1975889977 title "Tinkering Evolution of Post-Transcriptional RNA Regulons: Puf3p in Fungi as an Example" @default.
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- W1975889977 doi "https://doi.org/10.1371/journal.pgen.1001030" @default.
- W1975889977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2908677" @default.
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