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- W1975896062 abstract "Abstract Effects of diet on acetate incorporation into cholesterol and fatty acids in liver slices, and on the level of plasma cholesterol, were studied in rats and rabbits. Feeding fats and oils in a com‐mercial diet stimulated acetate incorporation into rat‐liver cholesterol much more than feeding them in a semisynthetic diet. This effect seemed to be specific for cholesterol since incorporation into fatty acids was not similarly affected. High levels of dietary casein inhibited acetate incorporation into both cholesterol and fatty acids. Rat‐liver slices generally incorporated more acetate into cholesterol than rabbit‐liver slices, but incorpora‐tion into fatty acids was often higher in the latter. Rabbit plasma cholesterols were higher on butter diets than on corn oil diets. Further eleva‐tion of plasma cholesterol was observed when casein was added to the butter diet but not when it was added to the corn oil diet. Plasma cho‐lesterols were elevated, and acetate incorporation into liver cholesterol and fatty acids was inhibited in suckling rats and rabbits whereas recently weaned animals gave results similar to those of adults. The inverse relationship between plasma cholesterol level and acetate incorporation into cholesterol may be attributable to feedback con‐trol of liver cholesterol biosynthesis. Other mechanisms which may account for the observed effects of dietary fats and protein on cholesterol metabolism, and the possible relevance of the findings to atherosclerosis, are discussed." @default.
- W1975896062 created "2016-06-24" @default.
- W1975896062 creator A5080898093 @default.
- W1975896062 date "1967-11-01" @default.
- W1975896062 modified "2023-10-14" @default.
- W1975896062 title "Diet, cholesterol metabolism, and atherosclerosis" @default.
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- W1975896062 doi "https://doi.org/10.1007/bf02680028" @default.
- W1975896062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6063666" @default.
- W1975896062 hasPublicationYear "1967" @default.
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