Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975907931> ?p ?o ?g. }
- W1975907931 endingPage "418" @default.
- W1975907931 startingPage "410" @default.
- W1975907931 abstract "Gestational diabetes (GDM) is associated with long-term cardiovascular and metabolic diseases in offspring. However, the mechanisms are not well understood. We explored whether fetal exposure to a diabetic environment is associated with fetal endothelial progenitor cell dysfunction, and whether vitamin D can reverse the impairment.Nineteen women with uncomplicated pregnancies and 18 women with GDM were recruited before delivery. Time to first appearance of endothelial colony forming cell (ECFC) colonies and number of ECFC colonies formed from culture of cord peripheral blood mononuclear cells were determined. Angiogenesis-related functions of ECFCs in vitro were tested in the presence or absence of vitamin D.Fetal ECFCs from GDM pregnancies formed fewer colonies in culture (P = 0.04) and displayed reduced proliferation (P = 0.02), migration (P = 0.04) and tubule formation (P = 0.03) compared to uncomplicated pregnancies. Fetal ECFCs exposed to hyperglycemia in vitro exhibited less migration (P < 0.05) and less tubule formation (P < 0.05) than normoglycemic control. Vitamin D significantly improved the dysfunction of fetal ECFCs from pregnancies complicated by GDM or after exposure of healthy ECFCs to hyperglycemia.Fetal ECFCs from GDM pregnancies or ECFCs exposed to hyperglycemia in vitro exhibit reduced quantity and impaired angiogenesis-related functions. Vitamin D significantly rescues these functions. These findings may have implications for vascular function of infants exposed to a diabetic intrauterine environment." @default.
- W1975907931 created "2016-06-24" @default.
- W1975907931 creator A5001140861 @default.
- W1975907931 creator A5014550072 @default.
- W1975907931 creator A5027385851 @default.
- W1975907931 creator A5073427952 @default.
- W1975907931 creator A5078108250 @default.
- W1975907931 creator A5080587659 @default.
- W1975907931 creator A5081844561 @default.
- W1975907931 date "2015-04-01" @default.
- W1975907931 modified "2023-09-25" @default.
- W1975907931 title "Vitamin D rescues dysfunction of fetal endothelial colony forming cells from individuals with gestational diabetes" @default.
- W1975907931 cites W1499254243 @default.
- W1975907931 cites W1508530364 @default.
- W1975907931 cites W1963789088 @default.
- W1975907931 cites W1977224635 @default.
- W1975907931 cites W1978243978 @default.
- W1975907931 cites W1983838150 @default.
- W1975907931 cites W1992234764 @default.
- W1975907931 cites W1993378051 @default.
- W1975907931 cites W1995585139 @default.
- W1975907931 cites W1999365413 @default.
- W1975907931 cites W2003143050 @default.
- W1975907931 cites W2009961905 @default.
- W1975907931 cites W2016558469 @default.
- W1975907931 cites W2029986937 @default.
- W1975907931 cites W2035489545 @default.
- W1975907931 cites W2045372180 @default.
- W1975907931 cites W2046039331 @default.
- W1975907931 cites W2055889558 @default.
- W1975907931 cites W2059147235 @default.
- W1975907931 cites W2067359824 @default.
- W1975907931 cites W2067687117 @default.
- W1975907931 cites W2074994370 @default.
- W1975907931 cites W2080548775 @default.
- W1975907931 cites W2087912166 @default.
- W1975907931 cites W2093942550 @default.
- W1975907931 cites W2094142721 @default.
- W1975907931 cites W2095081577 @default.
- W1975907931 cites W2100043942 @default.
- W1975907931 cites W2104372526 @default.
- W1975907931 cites W2118805045 @default.
- W1975907931 cites W2124070987 @default.
- W1975907931 cites W2125585377 @default.
- W1975907931 cites W2128260029 @default.
- W1975907931 cites W2131264460 @default.
- W1975907931 cites W2132096646 @default.
- W1975907931 cites W2133417600 @default.
- W1975907931 cites W2145203458 @default.
- W1975907931 cites W2145524503 @default.
- W1975907931 cites W2149091090 @default.
- W1975907931 cites W2158615121 @default.
- W1975907931 cites W2158644889 @default.
- W1975907931 cites W2159206233 @default.
- W1975907931 cites W2159384382 @default.
- W1975907931 cites W2168046808 @default.
- W1975907931 cites W2168207458 @default.
- W1975907931 cites W2616235706 @default.
- W1975907931 cites W4250711628 @default.
- W1975907931 doi "https://doi.org/10.1016/j.placenta.2015.01.195" @default.
- W1975907931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25684656" @default.
- W1975907931 hasPublicationYear "2015" @default.
- W1975907931 type Work @default.
- W1975907931 sameAs 1975907931 @default.
- W1975907931 citedByCount "25" @default.
- W1975907931 countsByYear W19759079312015 @default.
- W1975907931 countsByYear W19759079312016 @default.
- W1975907931 countsByYear W19759079312017 @default.
- W1975907931 countsByYear W19759079312018 @default.
- W1975907931 countsByYear W19759079312019 @default.
- W1975907931 countsByYear W19759079312020 @default.
- W1975907931 countsByYear W19759079312021 @default.
- W1975907931 countsByYear W19759079312022 @default.
- W1975907931 countsByYear W19759079312023 @default.
- W1975907931 crossrefType "journal-article" @default.
- W1975907931 hasAuthorship W1975907931A5001140861 @default.
- W1975907931 hasAuthorship W1975907931A5014550072 @default.
- W1975907931 hasAuthorship W1975907931A5027385851 @default.
- W1975907931 hasAuthorship W1975907931A5073427952 @default.
- W1975907931 hasAuthorship W1975907931A5078108250 @default.
- W1975907931 hasAuthorship W1975907931A5080587659 @default.
- W1975907931 hasAuthorship W1975907931A5081844561 @default.
- W1975907931 hasConcept C112672928 @default.
- W1975907931 hasConcept C126322002 @default.
- W1975907931 hasConcept C134018914 @default.
- W1975907931 hasConcept C137061746 @default.
- W1975907931 hasConcept C16685009 @default.
- W1975907931 hasConcept C172680121 @default.
- W1975907931 hasConcept C201750760 @default.
- W1975907931 hasConcept C202751555 @default.
- W1975907931 hasConcept C2779234561 @default.
- W1975907931 hasConcept C2779434492 @default.
- W1975907931 hasConcept C2780394083 @default.
- W1975907931 hasConcept C28328180 @default.
- W1975907931 hasConcept C46973012 @default.
- W1975907931 hasConcept C54355233 @default.
- W1975907931 hasConcept C55493867 @default.
- W1975907931 hasConcept C555293320 @default.