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• W1975918891 abstract "A constitutive complex of β-catenin and LEF-1 has been detected in melanoma cell lines expressing either mutant β-catenin or mutant APC (Rubinfeld et al., Science, 275, 1790–1792, 1997). However, it has been recently reported that β-catenin mutations are rare in primary malignant melanoma, but its nuclear and/or cytoplasmic localization, a potential indicator of Wnt/β-catenin pathway activation, is frequently observed in melanoma (Rimm et al., Am. J. Pathol., 154, 325–329, 1999). In human malignant melanoma, the appearance of the tumorigenic phase represents a capacity for metastasis and is the significant phenotypic step in disease progression. Cell motility in invasive melanoma is thought to play a crucial role in metastatic behavior. In this work, we sought to determine which transcription factor of the LEF/TCF family was preferentially involved in human melanoma from different stages of tumor progression. We show that LEF-1 mRNA expression is predominant in highly migrating cells from metastatic melanomas. These actively migrating melanoma cells showed nuclear and cytoplasmic accumulation of β-catenin and active transcription from a reporter plasmid of the LEF/TCF binding site. These results may provide a new insight into the role of the Wnt/β-catenin signaling pathway in the tumor progression of malignant melanoma." @default.
• W1975918891 created "2016-06-24" @default.
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• W1975918891 date "2001-10-01" @default.
• W1975918891 modified "2023-10-16" @default.
• W1975918891 title "Constitutive Activation of Wnt/β-Catenin Signaling Pathway in Migration-Active Melanoma Cells: Role of LEF-1 in Melanoma with Increased Metastatic Potential" @default.
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• W1975918891 doi "https://doi.org/10.1006/bbrc.2001.5719" @default.
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