Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975928077> ?p ?o ?g. }
- W1975928077 endingPage "409" @default.
- W1975928077 startingPage "399" @default.
- W1975928077 abstract "Different species of Leishmania can cause a variety of medically important diseases, whose control and treatment are still health problems. Telomere binding proteins (TBPs) have potential as targets for anti-parasitic chemotherapy because of their importance for genome stability and cell viability. Here, we describe LaTBP1 a protein that has a Myb-like DNA-binding domain, a feature shared by most double-stranded telomeric proteins. Binding assays using full-length and truncated LaTBP1 combined with spectroscopy analysis were used to map the boundaries of the Myb-like domain near to the protein only tryptophan residue. The Myb-like domain of LaTBP1 contains a conserved hydrophobic cavity implicated in DNA-binding activity. A hypothetical model helped to visualize that it shares structural homology with domains of other Myb-containing proteins. Competition assays and chromatin immunoprecipitation confirmed the specificity of LaTBP1 for telomeric and GT-rich DNAs, suggesting that LaTBP1 is a new TBP." @default.
- W1975928077 created "2016-06-24" @default.
- W1975928077 creator A5002855081 @default.
- W1975928077 creator A5021778596 @default.
- W1975928077 creator A5030040183 @default.
- W1975928077 creator A5040352776 @default.
- W1975928077 creator A5050322266 @default.
- W1975928077 creator A5053669969 @default.
- W1975928077 creator A5070996818 @default.
- W1975928077 creator A5083958989 @default.
- W1975928077 date "2007-09-01" @default.
- W1975928077 modified "2023-09-26" @default.
- W1975928077 title "LaTBP1: A Leishmania amazonensis DNA-binding protein that associates in vivo with telomeres and GT-rich DNA using a Myb-like domain" @default.
- W1975928077 cites W1521958691 @default.
- W1975928077 cites W1581288648 @default.
- W1975928077 cites W1615898285 @default.
- W1975928077 cites W1871829615 @default.
- W1975928077 cites W1929226344 @default.
- W1975928077 cites W1948178819 @default.
- W1975928077 cites W1958024510 @default.
- W1975928077 cites W1969889044 @default.
- W1975928077 cites W1986191025 @default.
- W1975928077 cites W1990478758 @default.
- W1975928077 cites W1993745063 @default.
- W1975928077 cites W1997619669 @default.
- W1975928077 cites W2003798106 @default.
- W1975928077 cites W2007452601 @default.
- W1975928077 cites W2012677653 @default.
- W1975928077 cites W2026557194 @default.
- W1975928077 cites W2028320710 @default.
- W1975928077 cites W2030019046 @default.
- W1975928077 cites W2033731825 @default.
- W1975928077 cites W2034746027 @default.
- W1975928077 cites W2036232454 @default.
- W1975928077 cites W2039831352 @default.
- W1975928077 cites W2045571168 @default.
- W1975928077 cites W2049992533 @default.
- W1975928077 cites W2050769764 @default.
- W1975928077 cites W2051475617 @default.
- W1975928077 cites W2051990601 @default.
- W1975928077 cites W2061810442 @default.
- W1975928077 cites W2065283382 @default.
- W1975928077 cites W2081095725 @default.
- W1975928077 cites W2087011288 @default.
- W1975928077 cites W2091780894 @default.
- W1975928077 cites W2098987256 @default.
- W1975928077 cites W2103202621 @default.
- W1975928077 cites W2111330606 @default.
- W1975928077 cites W2113168077 @default.
- W1975928077 cites W2115658418 @default.
- W1975928077 cites W2119586900 @default.
- W1975928077 cites W2126223002 @default.
- W1975928077 cites W2129014166 @default.
- W1975928077 cites W2130600682 @default.
- W1975928077 cites W2132294639 @default.
- W1975928077 cites W2132458897 @default.
- W1975928077 cites W2133885656 @default.
- W1975928077 cites W2145009758 @default.
- W1975928077 cites W2145952889 @default.
- W1975928077 cites W2149956398 @default.
- W1975928077 cites W2155159495 @default.
- W1975928077 cites W2158645345 @default.
- W1975928077 cites W2159371532 @default.
- W1975928077 cites W2160185049 @default.
- W1975928077 cites W2168799765 @default.
- W1975928077 cites W2410589421 @default.
- W1975928077 cites W4231439640 @default.
- W1975928077 doi "https://doi.org/10.1016/j.abb.2007.06.020" @default.
- W1975928077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17678615" @default.
- W1975928077 hasPublicationYear "2007" @default.
- W1975928077 type Work @default.
- W1975928077 sameAs 1975928077 @default.
- W1975928077 citedByCount "10" @default.
- W1975928077 countsByYear W19759280772012 @default.
- W1975928077 countsByYear W19759280772013 @default.
- W1975928077 countsByYear W19759280772014 @default.
- W1975928077 countsByYear W19759280772017 @default.
- W1975928077 countsByYear W19759280772018 @default.
- W1975928077 countsByYear W19759280772021 @default.
- W1975928077 crossrefType "journal-article" @default.
- W1975928077 hasAuthorship W1975928077A5002855081 @default.
- W1975928077 hasAuthorship W1975928077A5021778596 @default.
- W1975928077 hasAuthorship W1975928077A5030040183 @default.
- W1975928077 hasAuthorship W1975928077A5040352776 @default.
- W1975928077 hasAuthorship W1975928077A5050322266 @default.
- W1975928077 hasAuthorship W1975928077A5053669969 @default.
- W1975928077 hasAuthorship W1975928077A5070996818 @default.
- W1975928077 hasAuthorship W1975928077A5083958989 @default.
- W1975928077 hasConcept C101762097 @default.
- W1975928077 hasConcept C104317684 @default.
- W1975928077 hasConcept C134320426 @default.
- W1975928077 hasConcept C150194340 @default.
- W1975928077 hasConcept C153911025 @default.
- W1975928077 hasConcept C202265312 @default.
- W1975928077 hasConcept C33987129 @default.
- W1975928077 hasConcept C5179208 @default.
- W1975928077 hasConcept C54355233 @default.
- W1975928077 hasConcept C552990157 @default.