Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975938863> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1975938863 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILThe functional interaction between integrin α6β4 and growth factor receptors has been implicated in key signaling pathways important for cancer cell function. However, few attempts have been made to selectively target this interaction for therapeutic intervention. Previous studies showed that curcumin, a yellow pigment isolated from tumeric, inhibits integrin α6β4 signaling important for breast carcinoma cell motility and invasion, but the mechanism is not currently known. To address this issue, we tested the hypothesis that curcumin inhibits the functional interaction between α6β4 and the epidermal growth factor receptor (EGFR). In this study, we found that curcumin disrupts functional and physical interactions between α6β4 and EGFR, and blocks α6β4/EGFR dependent functions of carcinoma cells expressing the signaling competent form of α6β4. We further demonstrated that curcumin inhibits EGF dependent mobilization of α6β4 from hemidesmosomes to the leading edges of migrating cells such as lammelipodia and filopodia, and thereby prevents α6β4 distribution to lipid rafts where functional interactions between α6β4 and EGFR occur. These data suggest a novel paradigm in which curcumin inhibits α6β4 signaling and functions by altering intracellular localization of α6β4, thus preventing its association with signaling receptors such as EGFR.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1610. doi:1538-7445.AM2012-1610" @default.
- W1975938863 created "2016-06-24" @default.
- W1975938863 creator A5015847584 @default.
- W1975938863 creator A5026694504 @default.
- W1975938863 date "2012-04-15" @default.
- W1975938863 modified "2023-09-25" @default.
- W1975938863 title "Abstract 1610: Curcumin inhibition of the functional interaction between integrin α6β4 and the epidermal growth factor receptor" @default.
- W1975938863 doi "https://doi.org/10.1158/1538-7445.am2012-1610" @default.
- W1975938863 hasPublicationYear "2012" @default.
- W1975938863 type Work @default.
- W1975938863 sameAs 1975938863 @default.
- W1975938863 citedByCount "0" @default.
- W1975938863 crossrefType "proceedings-article" @default.
- W1975938863 hasAuthorship W1975938863A5015847584 @default.
- W1975938863 hasAuthorship W1975938863A5026694504 @default.
- W1975938863 hasConcept C121608353 @default.
- W1975938863 hasConcept C126322002 @default.
- W1975938863 hasConcept C170493617 @default.
- W1975938863 hasConcept C195687474 @default.
- W1975938863 hasConcept C2776362946 @default.
- W1975938863 hasConcept C2778250585 @default.
- W1975938863 hasConcept C2779438470 @default.
- W1975938863 hasConcept C502942594 @default.
- W1975938863 hasConcept C62478195 @default.
- W1975938863 hasConcept C71924100 @default.
- W1975938863 hasConcept C86803240 @default.
- W1975938863 hasConcept C95444343 @default.
- W1975938863 hasConcept C96232424 @default.
- W1975938863 hasConcept C98274493 @default.
- W1975938863 hasConceptScore W1975938863C121608353 @default.
- W1975938863 hasConceptScore W1975938863C126322002 @default.
- W1975938863 hasConceptScore W1975938863C170493617 @default.
- W1975938863 hasConceptScore W1975938863C195687474 @default.
- W1975938863 hasConceptScore W1975938863C2776362946 @default.
- W1975938863 hasConceptScore W1975938863C2778250585 @default.
- W1975938863 hasConceptScore W1975938863C2779438470 @default.
- W1975938863 hasConceptScore W1975938863C502942594 @default.
- W1975938863 hasConceptScore W1975938863C62478195 @default.
- W1975938863 hasConceptScore W1975938863C71924100 @default.
- W1975938863 hasConceptScore W1975938863C86803240 @default.
- W1975938863 hasConceptScore W1975938863C95444343 @default.
- W1975938863 hasConceptScore W1975938863C96232424 @default.
- W1975938863 hasConceptScore W1975938863C98274493 @default.
- W1975938863 hasLocation W19759388631 @default.
- W1975938863 hasOpenAccess W1975938863 @default.
- W1975938863 hasPrimaryLocation W19759388631 @default.
- W1975938863 hasRelatedWork W1527884948 @default.
- W1975938863 hasRelatedWork W1596416001 @default.
- W1975938863 hasRelatedWork W1995577203 @default.
- W1975938863 hasRelatedWork W2012688846 @default.
- W1975938863 hasRelatedWork W2033609024 @default.
- W1975938863 hasRelatedWork W2049620656 @default.
- W1975938863 hasRelatedWork W2050240006 @default.
- W1975938863 hasRelatedWork W2052605039 @default.
- W1975938863 hasRelatedWork W2053668040 @default.
- W1975938863 hasRelatedWork W2070421952 @default.
- W1975938863 hasRelatedWork W2156376058 @default.
- W1975938863 hasRelatedWork W2317785746 @default.
- W1975938863 hasRelatedWork W2559362891 @default.
- W1975938863 hasRelatedWork W2563021880 @default.
- W1975938863 hasRelatedWork W2564636141 @default.
- W1975938863 hasRelatedWork W2615601352 @default.
- W1975938863 hasRelatedWork W2885309105 @default.
- W1975938863 hasRelatedWork W2887078648 @default.
- W1975938863 hasRelatedWork W2955011348 @default.
- W1975938863 hasRelatedWork W2975108701 @default.
- W1975938863 isParatext "false" @default.
- W1975938863 isRetracted "false" @default.
- W1975938863 magId "1975938863" @default.
- W1975938863 workType "article" @default.