FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975941259> ?p ?o ?g. }

• W1975941259 endingPage "192" @default.
• W1975941259 startingPage "188" @default.
• W1975941259 abstract "Axonal transport of neurofilaments (NFs) has long been considered to be regulated by phosphorylation, although recent studies have challenged this hypothesis. Our prior analyses of axonal transport in optic axons demonstrated two distinct NF transport rates that spatially and temporally correlated with changes in NF phosphorylation. In our prior studies, we focused on subunits already within axons. Re-examination of these data using additional approaches and examining additional earlier time points have allowed us to calculate rates at which subunits transport out of retinas and into optic axons. NF subunits were radiolabeled by intravitreal injection of 35S-methionine. NF axonal transport was monitored by following the location of the front of radiolabeled subunits immunoprecipitated from retinas and segments of optic axons, which demonstrated four distinct transport rates. Subunits within retinas exhibited the fastest rate, and underwent a 50% slowing upon exiting the retina and entering optic axons. While this slowing could be due to a regional caliber increase and/or regional increase in NF phosphorylation within the first segment, prior studies indicated that inhibition of phosphatase activities increased NF phosphorylation within retinas and slowed NF subunit exit from retinas to a degree similar to that normally observed within the first segment of axons, suggesting that regional phosphorylation played a major role in slowing of NF transport following their exit from the retina. These findings provide additional support for the notion that phosphorylation regulates NF axonal transport." @default.
• W1975941259 created "2016-06-24" @default.
• W1975941259 creator A5009422295 @default.
• W1975941259 creator A5059634441 @default.
• W1975941259 date "2004-03-01" @default.
• W1975941259 modified "2023-10-14" @default.
• W1975941259 title "Neurofilament subunits undergo more rapid translocation within retinas than in optic axons" @default.
• W1975941259 cites W1573139030 @default.
• W1975941259 cites W1861316716 @default.
• W1975941259 cites W1899517605 @default.
• W1975941259 cites W1933602774 @default.
• W1975941259 cites W196564879 @default.
• W1975941259 cites W1966720057 @default.
• W1975941259 cites W1969573259 @default.
• W1975941259 cites W1974697888 @default.
• W1975941259 cites W1981439142 @default.
• W1975941259 cites W1982647438 @default.
• W1975941259 cites W1985812526 @default.
• W1975941259 cites W1987847886 @default.
• W1975941259 cites W1994245638 @default.
• W1975941259 cites W2006185924 @default.
• W1975941259 cites W2016148113 @default.
• W1975941259 cites W2021237157 @default.
• W1975941259 cites W2034850523 @default.
• W1975941259 cites W2056240446 @default.
• W1975941259 cites W2056274705 @default.
• W1975941259 cites W2062827892 @default.
• W1975941259 cites W2070513035 @default.
• W1975941259 cites W2073982144 @default.
• W1975941259 cites W2075256849 @default.
• W1975941259 cites W2075387470 @default.
• W1975941259 cites W2086325377 @default.
• W1975941259 cites W2099287762 @default.
• W1975941259 cites W2101356420 @default.
• W1975941259 cites W2103868443 @default.
• W1975941259 cites W2106218338 @default.
• W1975941259 cites W2106807815 @default.
• W1975941259 cites W2127124583 @default.
• W1975941259 cites W2133400638 @default.
• W1975941259 cites W2146014141 @default.
• W1975941259 cites W2151512547 @default.
• W1975941259 cites W2170383579 @default.
• W1975941259 cites W4256675099 @default.
• W1975941259 doi "https://doi.org/10.1016/j.molbrainres.2003.10.008" @default.
• W1975941259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15010211" @default.
• W1975941259 hasPublicationYear "2004" @default.
• W1975941259 type Work @default.
• W1975941259 sameAs 1975941259 @default.
• W1975941259 citedByCount "13" @default.
• W1975941259 countsByYear W19759412592014 @default.
• W1975941259 countsByYear W19759412592016 @default.
• W1975941259 crossrefType "journal-article" @default.
• W1975941259 hasAuthorship W1975941259A5009422295 @default.
• W1975941259 hasAuthorship W1975941259A5059634441 @default.
• W1975941259 hasConcept C104292427 @default.
• W1975941259 hasConcept C104317684 @default.
• W1975941259 hasConcept C11960822 @default.
• W1975941259 hasConcept C157207234 @default.
• W1975941259 hasConcept C169760540 @default.
• W1975941259 hasConcept C203014093 @default.
• W1975941259 hasConcept C204232928 @default.
• W1975941259 hasConcept C2777093970 @default.
• W1975941259 hasConcept C2779530196 @default.
• W1975941259 hasConcept C2780837183 @default.
• W1975941259 hasConcept C55493867 @default.
• W1975941259 hasConcept C70192387 @default.
• W1975941259 hasConcept C86803240 @default.
• W1975941259 hasConcept C95444343 @default.
• W1975941259 hasConceptScore W1975941259C104292427 @default.
• W1975941259 hasConceptScore W1975941259C104317684 @default.
• W1975941259 hasConceptScore W1975941259C11960822 @default.
• W1975941259 hasConceptScore W1975941259C157207234 @default.
• W1975941259 hasConceptScore W1975941259C169760540 @default.
• W1975941259 hasConceptScore W1975941259C203014093 @default.
• W1975941259 hasConceptScore W1975941259C204232928 @default.
• W1975941259 hasConceptScore W1975941259C2777093970 @default.
• W1975941259 hasConceptScore W1975941259C2779530196 @default.
• W1975941259 hasConceptScore W1975941259C2780837183 @default.
• W1975941259 hasConceptScore W1975941259C55493867 @default.
• W1975941259 hasConceptScore W1975941259C70192387 @default.
• W1975941259 hasConceptScore W1975941259C86803240 @default.
• W1975941259 hasConceptScore W1975941259C95444343 @default.
• W1975941259 hasIssue "2" @default.
• W1975941259 hasLocation W19759412591 @default.
• W1975941259 hasLocation W19759412592 @default.
• W1975941259 hasOpenAccess W1975941259 @default.
• W1975941259 hasPrimaryLocation W19759412591 @default.
• W1975941259 hasRelatedWork W1608212082 @default.
• W1975941259 hasRelatedWork W1980297066 @default.
• W1975941259 hasRelatedWork W1982652055 @default.
• W1975941259 hasRelatedWork W1984660473 @default.
• W1975941259 hasRelatedWork W2054202197 @default.
• W1975941259 hasRelatedWork W2085222224 @default.
• W1975941259 hasRelatedWork W2086214994 @default.
• W1975941259 hasRelatedWork W2346137535 @default.
• W1975941259 hasRelatedWork W2938344088 @default.
• W1975941259 hasRelatedWork W2521772322 @default.
• W1975941259 hasVolume "122" @default.

• next