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- W1975947207 abstract "Ultra-purified trehalose dimycolate, “P3”, an agent with potent host-reactive and immunological properties, including the ability to enhance tumor immune responses, was isolated from various strains of Mycobacterium tuberculosis, M. bovis, M. avium, or M. phlei and subjected to per-trimethylsilylation to permit chromatographic resolution of trehalose dimycolates containing different pairs of mycolic acids. Samples of trimethylsilylated P3 from virulent strains of human and bovine tubercle bacilli were resolved into six different components based on pairs of α, β, and γ-mycolic acids, whereas P3 from avirulent or attenuated strains contained fewer components due to the absence of detectable β-mycolic acid-containing diesters. The virulence of pathogenic mycobacteria may depend to a significant extent upon the presence or absence of a given component." @default.
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- W1975947207 date "1977-07-01" @default.
- W1975947207 modified "2023-09-25" @default.
- W1975947207 title "Separation of the mixture of trehalose 6,6′-dimycolates comprising the mycobacterial glycolipid fraction, “P3”" @default.
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- W1975947207 doi "https://doi.org/10.1016/s0006-291x(77)80001-6" @default.
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