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• W1975951517 abstract "Human immunodeficiency virus type I (HIV-1)-derived envelope glycoprotein 120 (gp120) is proposed to play an important role in HIV-1 neuropathology. Gp120 may act through mediators including proinflammatory cytokines. Here, we investigated the regulation of the IL-1beta system [IL-1beta, IL-1 receptor type I (IL-1RI), IL-1 receptor antagonist (IL-1Ra)], TNF-alpha and TGF-alpha mRNAs in the rat central nervous system (CNS) in response to the constant intracerebroventricular (ICV) microinfusion of HIV-1 gp120 for 72 h and 144 h. The results show that gp120: (1) increased IL-1beta and IL-1Ra mRNAs levels in the same samples from the cerebellum, hypothalamus and midbrain, with the largest increase in the hypothalamus; (2) induced profiles of IL-1beta mRNA and IL-1Ra mRNA that were highly intercorrelated; (3) increased the hypothalamic TNF-alpha mRNA levels; and (4) did not affect the IL-1RI mRNA and TGF-alpha mRNA levels in any brain region. A dysregulation in the IL-1beta/IL-1Ra CNS balance and a mutual induction and synergistic activity of IL-1beta and TNF-alpha could result in a deleterious amplification cycle of cellular activation and cytotoxicity with implications to HIV-1-associated encephalitis, encephalopathy, and neurological manifestations." @default.
• W1975951517 created "2016-06-24" @default.
• W1975951517 creator A5067587676 @default.
• W1975951517 creator A5084304065 @default.
• W1975951517 date "1997-01-01" @default.
• W1975951517 modified "2023-10-13" @default.
• W1975951517 title "HIV-1 Envelope Glycoprotein 120 Regulates Brain IL-1 β System and TNF- α mRNAs In Vivo" @default.
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• W1975951517 doi "https://doi.org/10.1016/s0361-9230(97)00091-9" @default.
• W1975951517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9288832" @default.
• W1975951517 hasPublicationYear "1997" @default.
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