FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975967573> ?p ?o ?g. }

• W1975967573 endingPage "101" @default.
• W1975967573 startingPage "73" @default.
• W1975967573 abstract "Ionizing radiation (IR) can produce deleterious effects in living tissues, leading to significant morbidity and a potentially fatal illness affecting various organs dose-dependently. As people may be exposed to IR during cancer radiotherapy or as a result of a radiological/nuclear incident or act of terrorism, the danger of irradiation represents a serious public health problem. At present, however, this problem remains largely impervious to medical management. There is, therefore, a pressing need to develop safe and effective radiation countermeasure (RC) agents to prevent, mitigate or treat the harmful consequences of IR exposure.Recent advances in the search for RC agents as reflected by the relevant patent literature of the past five years along with peer-reviewed publications are surveyed.A total of 43 patents, describing approximately 38 chemically diverse compounds with RC potential are analyzed. These include antioxidants capable of scavenging IR-induced free radicals, modulators of cell death signaling or cell cycle progression, cytokines or growth factors promoting tissue repair and inhibitors of inflammatory cytokines.Several of these RC candidates appear promising, including at least two that are undergoing evaluation for fast-track clinical development." @default.
• W1975967573 created "2016-06-24" @default.
• W1975967573 creator A5016281103 @default.
• W1975967573 creator A5026216117 @default.
• W1975967573 creator A5045221580 @default.
• W1975967573 date "2009-12-20" @default.
• W1975967573 modified "2023-09-25" @default.
• W1975967573 title "Radiation countermeasure agents: an update" @default.
• W1975967573 cites W148055779 @default.
• W1975967573 cites W149739268 @default.
• W1975967573 cites W152873362 @default.
• W1975967573 cites W1841031971 @default.
• W1975967573 cites W1966452335 @default.
• W1975967573 cites W1966731347 @default.
• W1975967573 cites W1966895787 @default.
• W1975967573 cites W1973101427 @default.
• W1975967573 cites W1977292749 @default.
• W1975967573 cites W1979871496 @default.
• W1975967573 cites W1980106291 @default.
• W1975967573 cites W1984363929 @default.
• W1975967573 cites W1987628776 @default.
• W1975967573 cites W1990906371 @default.
• W1975967573 cites W1996809397 @default.
• W1975967573 cites W1997696481 @default.
• W1975967573 cites W1998228931 @default.
• W1975967573 cites W2000674394 @default.
• W1975967573 cites W2007680735 @default.
• W1975967573 cites W2007884086 @default.
• W1975967573 cites W2008212722 @default.
• W1975967573 cites W2016033405 @default.
• W1975967573 cites W2016899305 @default.
• W1975967573 cites W2017313100 @default.
• W1975967573 cites W2019486088 @default.
• W1975967573 cites W2020437368 @default.
• W1975967573 cites W2021174770 @default.
• W1975967573 cites W2021691817 @default.
• W1975967573 cites W2024601575 @default.
• W1975967573 cites W2025406984 @default.
• W1975967573 cites W2025631291 @default.
• W1975967573 cites W2026377273 @default.
• W1975967573 cites W2027239974 @default.
• W1975967573 cites W2027925555 @default.
• W1975967573 cites W2028040595 @default.
• W1975967573 cites W2029192296 @default.
• W1975967573 cites W2032572502 @default.
• W1975967573 cites W2035072375 @default.
• W1975967573 cites W2035751913 @default.
• W1975967573 cites W2038298358 @default.
• W1975967573 cites W2044351980 @default.
• W1975967573 cites W2046374080 @default.
• W1975967573 cites W2046396329 @default.
• W1975967573 cites W2047605904 @default.
• W1975967573 cites W2049119654 @default.
• W1975967573 cites W2051875036 @default.
• W1975967573 cites W2051971958 @default.
• W1975967573 cites W2054193305 @default.
• W1975967573 cites W2054253259 @default.
• W1975967573 cites W2055303877 @default.
• W1975967573 cites W2055687679 @default.
• W1975967573 cites W2057858743 @default.
• W1975967573 cites W2058786544 @default.
• W1975967573 cites W2062410438 @default.
• W1975967573 cites W2063131548 @default.
• W1975967573 cites W2068343980 @default.
• W1975967573 cites W2069198518 @default.
• W1975967573 cites W2071846634 @default.
• W1975967573 cites W2074969587 @default.
• W1975967573 cites W2076086088 @default.
• W1975967573 cites W2086273699 @default.
• W1975967573 cites W2089343039 @default.
• W1975967573 cites W2090192963 @default.
• W1975967573 cites W2091406076 @default.
• W1975967573 cites W2091504158 @default.
• W1975967573 cites W2092830118 @default.
• W1975967573 cites W2095492467 @default.
• W1975967573 cites W2095675546 @default.
• W1975967573 cites W2097227447 @default.
• W1975967573 cites W2099012753 @default.
• W1975967573 cites W2099990619 @default.
• W1975967573 cites W2101779262 @default.
• W1975967573 cites W2103486381 @default.
• W1975967573 cites W2103616303 @default.
• W1975967573 cites W2111193917 @default.
• W1975967573 cites W2111651157 @default.
• W1975967573 cites W2114196865 @default.
• W1975967573 cites W2114404055 @default.
• W1975967573 cites W2118063672 @default.
• W1975967573 cites W2123110273 @default.
• W1975967573 cites W2123328403 @default.
• W1975967573 cites W2124740651 @default.
• W1975967573 cites W2128463688 @default.
• W1975967573 cites W2132254460 @default.
• W1975967573 cites W2132785031 @default.
• W1975967573 cites W2133427348 @default.
• W1975967573 cites W2137116513 @default.
• W1975967573 cites W2137446112 @default.
• W1975967573 cites W2142645197 @default.
• W1975967573 cites W2146399077 @default.

• next