FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975976108> ?p ?o ?g. }

• W1975976108 endingPage "738" @default.
• W1975976108 startingPage "727" @default.
• W1975976108 abstract "The α2/δ1 subunit forms part of the dihydropyridine receptor, an essential protein complex for excitation–contraction (EC) coupling in skeletal muscle. Because of the lack of a viable knock‐out animal, little is known regarding the role of the α2/δ1 subunit in EC coupling or in other cell functions. Interestingly, the α2/δ1 appears before the α1 subunit in development and contains extracellular conserved domains known to be important in cell signalling and inter‐protein interactions. These facts raise the possibility that the α2/δ1 subunit performs vital functions not associated with EC coupling. Here, we tested the hypothesis that the α2/δ1 subunit is important for interactions of muscle cells with their environment. Using confocal microscopy, we followed the immunolocalization of α2/δ1 and α1 subunits with age. We found that in 2‐day‐old myotubes, the α2/δ1 subunit concentrated towards the ends of the cells, while the α1 subunit clustered near the centre. As myotubes aged (6–12 days), the α2/δ1 became evenly distributed along the myotubes and co‐localized with α1. When the expression of α2/δ1 was blocked with siRNA, migration, attachment and spreading of myoblasts were impaired while the L‐type calcium current remained unaffected. The results suggest a previously unidentified role of the α2/δ1 subunit in skeletal muscle and support the involvement of this protein in extracellular signalling. This new role of the α2/δ1 subunit may be crucial for muscle development, muscle repair and at times in which myoblast attachment and migration are fundamental." @default.
• W1975976108 created "2016-06-24" @default.
• W1975976108 creator A5031786575 @default.
• W1975976108 creator A5036597136 @default.
• W1975976108 creator A5044301311 @default.
• W1975976108 date "2008-02-01" @default.
• W1975976108 modified "2023-10-17" @default.
• W1975976108 title "The calcium channel α2/δ1 subunit is involved in extracellular signalling" @default.
• W1975976108 cites W1531875920 @default.
• W1975976108 cites W1570544530 @default.
• W1975976108 cites W1574967633 @default.
• W1975976108 cites W1603937713 @default.
• W1975976108 cites W1611419331 @default.
• W1975976108 cites W1625124567 @default.
• W1975976108 cites W1788488909 @default.
• W1975976108 cites W1902878432 @default.
• W1975976108 cites W1944685607 @default.
• W1975976108 cites W1968924035 @default.
• W1975976108 cites W1988143758 @default.
• W1975976108 cites W1990667380 @default.
• W1975976108 cites W1993315072 @default.
• W1975976108 cites W1997495355 @default.
• W1975976108 cites W2003758393 @default.
• W1975976108 cites W2004945910 @default.
• W1975976108 cites W2007607789 @default.
• W1975976108 cites W2009667219 @default.
• W1975976108 cites W2011434856 @default.
• W1975976108 cites W2016466873 @default.
• W1975976108 cites W2016547597 @default.
• W1975976108 cites W2016807756 @default.
• W1975976108 cites W2020714294 @default.
• W1975976108 cites W2026069493 @default.
• W1975976108 cites W2029426452 @default.
• W1975976108 cites W2034998738 @default.
• W1975976108 cites W2043361189 @default.
• W1975976108 cites W2045653120 @default.
• W1975976108 cites W2058397861 @default.
• W1975976108 cites W2061105731 @default.
• W1975976108 cites W2078360969 @default.
• W1975976108 cites W2081658042 @default.
• W1975976108 cites W2083670089 @default.
• W1975976108 cites W2097422370 @default.
• W1975976108 cites W2102896453 @default.
• W1975976108 cites W2115438428 @default.
• W1975976108 cites W2117630703 @default.
• W1975976108 cites W2143459920 @default.
• W1975976108 cites W2145479750 @default.
• W1975976108 cites W2146514170 @default.
• W1975976108 cites W2149538815 @default.
• W1975976108 cites W2157108608 @default.
• W1975976108 cites W2159874398 @default.
• W1975976108 cites W2169310627 @default.
• W1975976108 cites W4254936240 @default.
• W1975976108 cites W60195716 @default.
• W1975976108 cites W2044458477 @default.
• W1975976108 doi "https://doi.org/10.1113/jphysiol.2007.147959" @default.
• W1975976108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2375616" @default.
• W1975976108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18063658" @default.
• W1975976108 hasPublicationYear "2008" @default.
• W1975976108 type Work @default.
• W1975976108 sameAs 1975976108 @default.
• W1975976108 citedByCount "43" @default.
• W1975976108 countsByYear W19759761082012 @default.
• W1975976108 countsByYear W19759761082013 @default.
• W1975976108 countsByYear W19759761082014 @default.
• W1975976108 countsByYear W19759761082015 @default.
• W1975976108 countsByYear W19759761082016 @default.
• W1975976108 countsByYear W19759761082018 @default.
• W1975976108 countsByYear W19759761082020 @default.
• W1975976108 countsByYear W19759761082021 @default.
• W1975976108 countsByYear W19759761082022 @default.
• W1975976108 countsByYear W19759761082023 @default.
• W1975976108 crossrefType "journal-article" @default.
• W1975976108 hasAuthorship W1975976108A5031786575 @default.
• W1975976108 hasAuthorship W1975976108A5036597136 @default.
• W1975976108 hasAuthorship W1975976108A5044301311 @default.
• W1975976108 hasBestOaLocation W19759761082 @default.
• W1975976108 hasConcept C104292427 @default.
• W1975976108 hasConcept C104317684 @default.
• W1975976108 hasConcept C105702510 @default.
• W1975976108 hasConcept C113217602 @default.
• W1975976108 hasConcept C178790620 @default.
• W1975976108 hasConcept C185592680 @default.
• W1975976108 hasConcept C207200792 @default.
• W1975976108 hasConcept C2779959927 @default.
• W1975976108 hasConcept C28406088 @default.
• W1975976108 hasConcept C3763915 @default.
• W1975976108 hasConcept C519063684 @default.
• W1975976108 hasConcept C55493867 @default.
• W1975976108 hasConcept C79879829 @default.
• W1975976108 hasConcept C85520022 @default.
• W1975976108 hasConcept C86803240 @default.
• W1975976108 hasConcept C95444343 @default.
• W1975976108 hasConceptScore W1975976108C104292427 @default.
• W1975976108 hasConceptScore W1975976108C104317684 @default.
• W1975976108 hasConceptScore W1975976108C105702510 @default.
• W1975976108 hasConceptScore W1975976108C113217602 @default.
• W1975976108 hasConceptScore W1975976108C178790620 @default.

• next