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• W1975976477 abstract "The effect of the uremic solute indoxyl sulfate (IS) on scavenging superoxide anion radicals ( ) generated from both the xanthine/xanthine oxidase (X/XO) system and activated neutrophils was investigated by electron paramagnetic resonance spectroscopy, combined with 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide (EMPO). The findings show that the presence of normal-physiological serum concentrations of IS (0.1–10 μM) resulted in decreased formation of EMPO-superoxide adduct without affecting XO activity. Furthermore, IS showed scavenging activity against cell-derived generated from activated neutrophils. In addition, IS also eliminated hydroxyl radicals. These findings suggest that IS acts as a novel endogenous antioxidant under normal-physiological conditions." @default.
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• W1975976477 date "2010-04-21" @default.
• W1975976477 modified "2023-10-16" @default.
• W1975976477 title "The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions" @default.
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• W1975976477 doi "https://doi.org/10.1016/j.febslet.2010.04.046" @default.
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