Matches in SemOpenAlex for { <https://semopenalex.org/work/W197597788> ?p ?o ?g. }
- W197597788 endingPage "683" @default.
- W197597788 startingPage "671" @default.
- W197597788 abstract "Little is known about the functional interactions between digestive neuroendocrine tumor cells and their stromal microenvironment. The focus of our study is whether mesenchymal cells modulate peptide expression, cell proliferation, and invasiveness in digestive neuroendocrine tumor cells. We designed an experimental in vivo and in vitro study using the mouse enteroendocrine cell line STC-1. In vivo, STC-1 cells were injected subcutaneously in 18 immunosuppressed newborn rats. At day 21, all animals presented poorly differentiated neuroendocrine tumors with lung metastases. Subcutaneous tumors were usually limited by a capsule containing basement membrane components and myofibroblasts that presented a low mitotic index. Lung tumors were devoid of capsule and poor in myofibroblasts, and their mitotic index was high. The profile of peptide expression in STC-1 tumors was different from that of cultured STC-1 cells. In vitro, STC-1 cells were cultured with fibroblasts of different origins, including dermis, lung, digestive tract, and liver. Based on their origin, myofibroblasts differentially modulated hormone synthesis, proliferation, spreading, and adhesion of STC-1 cells. In conclusion, our results show that site-specific functional interactions between mesenchymal and neuroendocrine cells may contribute to modulating the behavior of digestive neuroendocrine tumors, depending on their growth site." @default.
- W197597788 created "2016-06-24" @default.
- W197597788 creator A5015300478 @default.
- W197597788 creator A5024872421 @default.
- W197597788 creator A5028901714 @default.
- W197597788 creator A5042575799 @default.
- W197597788 creator A5042883894 @default.
- W197597788 creator A5068506124 @default.
- W197597788 creator A5069979878 @default.
- W197597788 creator A5077313433 @default.
- W197597788 creator A5080911484 @default.
- W197597788 creator A5088468003 @default.
- W197597788 creator A5088999997 @default.
- W197597788 creator A5091564657 @default.
- W197597788 date "2000-02-01" @default.
- W197597788 modified "2023-10-17" @default.
- W197597788 title "Site-Specific Epithelial-Mesenchymal Interactions in Digestive Neuroendocrine Tumors" @default.
- W197597788 cites W1209009237 @default.
- W197597788 cites W1457049491 @default.
- W197597788 cites W148659409 @default.
- W197597788 cites W1615627891 @default.
- W197597788 cites W1624070697 @default.
- W197597788 cites W1643968031 @default.
- W197597788 cites W1788391538 @default.
- W197597788 cites W1964622585 @default.
- W197597788 cites W1984937605 @default.
- W197597788 cites W1999017992 @default.
- W197597788 cites W2007572139 @default.
- W197597788 cites W2015028428 @default.
- W197597788 cites W2021029245 @default.
- W197597788 cites W2021815403 @default.
- W197597788 cites W2033264708 @default.
- W197597788 cites W2037028097 @default.
- W197597788 cites W2037968512 @default.
- W197597788 cites W2039772820 @default.
- W197597788 cites W2040122812 @default.
- W197597788 cites W204536596 @default.
- W197597788 cites W2049399041 @default.
- W197597788 cites W2057103712 @default.
- W197597788 cites W2070531690 @default.
- W197597788 cites W2077216446 @default.
- W197597788 cites W2092121984 @default.
- W197597788 cites W2095945577 @default.
- W197597788 cites W2100258257 @default.
- W197597788 cites W2118057643 @default.
- W197597788 cites W2119521625 @default.
- W197597788 cites W2133013402 @default.
- W197597788 cites W2134571801 @default.
- W197597788 cites W2134812217 @default.
- W197597788 cites W2134955932 @default.
- W197597788 cites W2139371822 @default.
- W197597788 cites W2140273413 @default.
- W197597788 cites W2144942389 @default.
- W197597788 cites W2148205892 @default.
- W197597788 cites W2166236185 @default.
- W197597788 cites W2171717305 @default.
- W197597788 cites W2395492951 @default.
- W197597788 cites W2419676527 @default.
- W197597788 cites W2431294813 @default.
- W197597788 cites W2464660659 @default.
- W197597788 cites W38397700 @default.
- W197597788 cites W4294216491 @default.
- W197597788 doi "https://doi.org/10.1016/s0002-9440(10)64771-2" @default.
- W197597788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1850059" @default.
- W197597788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10666396" @default.
- W197597788 hasPublicationYear "2000" @default.
- W197597788 type Work @default.
- W197597788 sameAs 197597788 @default.
- W197597788 citedByCount "18" @default.
- W197597788 countsByYear W1975977882012 @default.
- W197597788 countsByYear W1975977882017 @default.
- W197597788 countsByYear W1975977882019 @default.
- W197597788 countsByYear W1975977882020 @default.
- W197597788 crossrefType "journal-article" @default.
- W197597788 hasAuthorship W197597788A5015300478 @default.
- W197597788 hasAuthorship W197597788A5024872421 @default.
- W197597788 hasAuthorship W197597788A5028901714 @default.
- W197597788 hasAuthorship W197597788A5042575799 @default.
- W197597788 hasAuthorship W197597788A5042883894 @default.
- W197597788 hasAuthorship W197597788A5068506124 @default.
- W197597788 hasAuthorship W197597788A5069979878 @default.
- W197597788 hasAuthorship W197597788A5077313433 @default.
- W197597788 hasAuthorship W197597788A5080911484 @default.
- W197597788 hasAuthorship W197597788A5088468003 @default.
- W197597788 hasAuthorship W197597788A5088999997 @default.
- W197597788 hasAuthorship W197597788A5091564657 @default.
- W197597788 hasBestOaLocation W1975977881 @default.
- W197597788 hasConcept C134018914 @default.
- W197597788 hasConcept C142724271 @default.
- W197597788 hasConcept C150903083 @default.
- W197597788 hasConcept C16930146 @default.
- W197597788 hasConcept C198826908 @default.
- W197597788 hasConcept C203014093 @default.
- W197597788 hasConcept C204232928 @default.
- W197597788 hasConcept C207001950 @default.
- W197597788 hasConcept C207865475 @default.
- W197597788 hasConcept C2776193487 @default.
- W197597788 hasConcept C2776340970 @default.