Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975979298> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1975979298 endingPage "S5" @default.
- W1975979298 startingPage "S3" @default.
- W1975979298 abstract "β 2 -Glycoprotein I (β 2 -GPI) is a cofactor in the recognition of a phospholipid antigen, cardiolipin, by anticardiolipin antibodies in autoimmune diseases such as systemic lupus erythematosus. We examined the interaction of various forms of bovine β 2 -GPI, such as its intact form, desialylated form (Asialo β 2 -GPI), N-terminal domain (domain 1) and the modified forms of β 2 -GPI and Asialo β 2 -GPI with nicks in their C-terminal domains (domain 5), with phospholipid liposomes under different conditions of pH and ionic strength. We found that at neutral pH and low ionic strength β 2 -GPI bound to liposome membranes containing cardiolipin with a dissociation constant (Kd) of 10 −8 M. Phosphatidylglycerol, phosphatidylserine, phosphatidic acid or phosphatidylinositol bound to β 2 -GPI, but phosphatidylcholine did not. We also found that domain 1 and Asialo β 2 -GPI bound to cardiolipin with Kd values of 10 −6 and 10 −8 M, respectively, At neutral pH and both low and high ionic strengths, the affinities of nicked forms of β 2 -GPI and Asialo β 2 -GPI for cardiolipin were lower than those of intact forms but similar to that of domain 1." @default.
- W1975979298 created "2016-06-24" @default.
- W1975979298 creator A5022600763 @default.
- W1975979298 creator A5038813552 @default.
- W1975979298 creator A5055364103 @default.
- W1975979298 creator A5080295889 @default.
- W1975979298 date "1995-02-01" @default.
- W1975979298 modified "2023-10-02" @default.
- W1975979298 title "Structure and Function of β<sub>2</sub>-Glycoprotein I: With Special Reference to the Interaction with Phospholipid" @default.
- W1975979298 cites W1969211427 @default.
- W1975979298 cites W2000886437 @default.
- W1975979298 cites W2014456395 @default.
- W1975979298 cites W2020070102 @default.
- W1975979298 cites W2023052741 @default.
- W1975979298 cites W2026161424 @default.
- W1975979298 cites W2039905764 @default.
- W1975979298 cites W2046838002 @default.
- W1975979298 cites W2080178350 @default.
- W1975979298 cites W2089463223 @default.
- W1975979298 cites W2091528120 @default.
- W1975979298 cites W2093870776 @default.
- W1975979298 cites W2113309875 @default.
- W1975979298 cites W2326745461 @default.
- W1975979298 doi "https://doi.org/10.1177/096120339400400102" @default.
- W1975979298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7757108" @default.
- W1975979298 hasPublicationYear "1995" @default.
- W1975979298 type Work @default.
- W1975979298 sameAs 1975979298 @default.
- W1975979298 citedByCount "6" @default.
- W1975979298 countsByYear W19759792982013 @default.
- W1975979298 countsByYear W19759792982014 @default.
- W1975979298 countsByYear W19759792982020 @default.
- W1975979298 crossrefType "journal-article" @default.
- W1975979298 hasAuthorship W1975979298A5022600763 @default.
- W1975979298 hasAuthorship W1975979298A5038813552 @default.
- W1975979298 hasAuthorship W1975979298A5055364103 @default.
- W1975979298 hasAuthorship W1975979298A5080295889 @default.
- W1975979298 hasConcept C108625454 @default.
- W1975979298 hasConcept C184235292 @default.
- W1975979298 hasConcept C185154212 @default.
- W1975979298 hasConcept C185592680 @default.
- W1975979298 hasConcept C22222904 @default.
- W1975979298 hasConcept C2776330855 @default.
- W1975979298 hasConcept C2776909261 @default.
- W1975979298 hasConcept C2778918659 @default.
- W1975979298 hasConcept C2779637612 @default.
- W1975979298 hasConcept C2780610907 @default.
- W1975979298 hasConcept C2780726299 @default.
- W1975979298 hasConcept C2781302388 @default.
- W1975979298 hasConcept C2909986158 @default.
- W1975979298 hasConcept C41625074 @default.
- W1975979298 hasConcept C55493867 @default.
- W1975979298 hasConceptScore W1975979298C108625454 @default.
- W1975979298 hasConceptScore W1975979298C184235292 @default.
- W1975979298 hasConceptScore W1975979298C185154212 @default.
- W1975979298 hasConceptScore W1975979298C185592680 @default.
- W1975979298 hasConceptScore W1975979298C22222904 @default.
- W1975979298 hasConceptScore W1975979298C2776330855 @default.
- W1975979298 hasConceptScore W1975979298C2776909261 @default.
- W1975979298 hasConceptScore W1975979298C2778918659 @default.
- W1975979298 hasConceptScore W1975979298C2779637612 @default.
- W1975979298 hasConceptScore W1975979298C2780610907 @default.
- W1975979298 hasConceptScore W1975979298C2780726299 @default.
- W1975979298 hasConceptScore W1975979298C2781302388 @default.
- W1975979298 hasConceptScore W1975979298C2909986158 @default.
- W1975979298 hasConceptScore W1975979298C41625074 @default.
- W1975979298 hasConceptScore W1975979298C55493867 @default.
- W1975979298 hasIssue "1_suppl" @default.
- W1975979298 hasLocation W19759792981 @default.
- W1975979298 hasLocation W19759792982 @default.
- W1975979298 hasOpenAccess W1975979298 @default.
- W1975979298 hasPrimaryLocation W19759792981 @default.
- W1975979298 hasRelatedWork W2015000256 @default.
- W1975979298 hasRelatedWork W2030262159 @default.
- W1975979298 hasRelatedWork W2034518346 @default.
- W1975979298 hasRelatedWork W2066851480 @default.
- W1975979298 hasRelatedWork W2073396018 @default.
- W1975979298 hasRelatedWork W2087022332 @default.
- W1975979298 hasRelatedWork W2089939568 @default.
- W1975979298 hasRelatedWork W2140273979 @default.
- W1975979298 hasRelatedWork W2472735355 @default.
- W1975979298 hasRelatedWork W2941149508 @default.
- W1975979298 hasVolume "4" @default.
- W1975979298 isParatext "false" @default.
- W1975979298 isRetracted "false" @default.
- W1975979298 magId "1975979298" @default.
- W1975979298 workType "article" @default.