Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975984114> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1975984114 endingPage "11" @default.
- W1975984114 startingPage "7" @default.
- W1975984114 abstract "Amitrole is a herbicide which has been found to induce thyroid and liver tumours in rodents, yet demonstrates limited genotoxic activity. The lack of mutagenicity of this compound in Salmonella typhimurium when employing a standard liver microsomal fraction, combined with evidence of activation of amitrole by peroxidases, warranted an investigation employing this other pathway of metabolic activation. Using prostaglandin H synthase as the activating system, the aromatic amine 2-aminofluorene provided a convenient positive control for optimisation of the metabolising system. Under such conditions, amitrole did not induce elevated numbers of revertant colonies in Salmonella typhimurium TA98, neither did it display evidence of interference with histidine biosynthesis as had been reported. Amitrole also remained nonmutagenic when preincubated at varying pHs. Thus, it has been shown that the alternative activation system, prostaglandin H synthase, does not produce metabolites which are mutagenic in the Ames test." @default.
- W1975984114 created "2016-06-24" @default.
- W1975984114 creator A5035041915 @default.
- W1975984114 creator A5035294084 @default.
- W1975984114 creator A5046782826 @default.
- W1975984114 date "1992-09-01" @default.
- W1975984114 modified "2023-10-18" @default.
- W1975984114 title "Evaluation of amitrole mutagenicity in Salmonella typhimurium using prostaglandin synthase activation" @default.
- W1975984114 cites W16523006 @default.
- W1975984114 cites W1971518661 @default.
- W1975984114 cites W1988153624 @default.
- W1975984114 cites W2001123019 @default.
- W1975984114 cites W2007796985 @default.
- W1975984114 cites W2018456600 @default.
- W1975984114 cites W2034384613 @default.
- W1975984114 cites W2061114430 @default.
- W1975984114 cites W2073540467 @default.
- W1975984114 cites W2081145185 @default.
- W1975984114 cites W2082183049 @default.
- W1975984114 cites W2082540538 @default.
- W1975984114 doi "https://doi.org/10.1016/0165-7992(92)90115-x" @default.
- W1975984114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1380667" @default.
- W1975984114 hasPublicationYear "1992" @default.
- W1975984114 type Work @default.
- W1975984114 sameAs 1975984114 @default.
- W1975984114 citedByCount "3" @default.
- W1975984114 crossrefType "journal-article" @default.
- W1975984114 hasAuthorship W1975984114A5035041915 @default.
- W1975984114 hasAuthorship W1975984114A5035294084 @default.
- W1975984114 hasAuthorship W1975984114A5046782826 @default.
- W1975984114 hasConcept C112243037 @default.
- W1975984114 hasConcept C117632636 @default.
- W1975984114 hasConcept C181199279 @default.
- W1975984114 hasConcept C185592680 @default.
- W1975984114 hasConcept C2780664492 @default.
- W1975984114 hasConcept C2781065037 @default.
- W1975984114 hasConcept C523546767 @default.
- W1975984114 hasConcept C54355233 @default.
- W1975984114 hasConcept C55493867 @default.
- W1975984114 hasConcept C86803240 @default.
- W1975984114 hasConcept C87644729 @default.
- W1975984114 hasConceptScore W1975984114C112243037 @default.
- W1975984114 hasConceptScore W1975984114C117632636 @default.
- W1975984114 hasConceptScore W1975984114C181199279 @default.
- W1975984114 hasConceptScore W1975984114C185592680 @default.
- W1975984114 hasConceptScore W1975984114C2780664492 @default.
- W1975984114 hasConceptScore W1975984114C2781065037 @default.
- W1975984114 hasConceptScore W1975984114C523546767 @default.
- W1975984114 hasConceptScore W1975984114C54355233 @default.
- W1975984114 hasConceptScore W1975984114C55493867 @default.
- W1975984114 hasConceptScore W1975984114C86803240 @default.
- W1975984114 hasConceptScore W1975984114C87644729 @default.
- W1975984114 hasIssue "1" @default.
- W1975984114 hasLocation W19759841141 @default.
- W1975984114 hasLocation W19759841142 @default.
- W1975984114 hasOpenAccess W1975984114 @default.
- W1975984114 hasPrimaryLocation W19759841141 @default.
- W1975984114 hasRelatedWork W1969528520 @default.
- W1975984114 hasRelatedWork W1975984114 @default.
- W1975984114 hasRelatedWork W2007857397 @default.
- W1975984114 hasRelatedWork W2039378186 @default.
- W1975984114 hasRelatedWork W207147950 @default.
- W1975984114 hasRelatedWork W2127957525 @default.
- W1975984114 hasRelatedWork W2150606317 @default.
- W1975984114 hasRelatedWork W243713034 @default.
- W1975984114 hasRelatedWork W2593657712 @default.
- W1975984114 hasRelatedWork W299641249 @default.
- W1975984114 hasVolume "283" @default.
- W1975984114 isParatext "false" @default.
- W1975984114 isRetracted "false" @default.
- W1975984114 magId "1975984114" @default.
- W1975984114 workType "article" @default.