Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975991837> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1975991837 endingPage "640" @default.
- W1975991837 startingPage "633" @default.
- W1975991837 abstract "OBJECTIVE: We initiated studies to develop cytokine-secreting human ovarian carcinoma cells for the purpose of using these cells as vaccines for the treatment of advanced epithelial ovarian cancer. STUDY DESIGN: A human ovarian carcinoma cell line (UCI-107) was genetically engineered to secrete the cytokine interleukin-2 by retroviral-mediated gene transduction. RESULTS: One clone, termed UCI-107A IL-2 AS, constitutively secreted high levels of interleukin-2 (i.e., 2000 to 2300 pg/ml/105 cells per 48 hours) for >55 passages and 8 months of study. Unlike parental- and vector-transduced cells, UCI-107A IL-2 AS cells were aneuploid and failed to express major histocompatibility complex class I and HER2/neu surface antigens. UCI-107A IL-2 AS cells were highly resistant to killing by gamma irradiation and continued to produce high levels of interleukin-2 even after irradiation with 10,000 cGy. Balb/C nude mice injected intraperitoneally with UCI-107A IL-2 AS cells survived significantly longer than control animals, with 25% of the animals totally rejecting their tumors. UCI-107A IL-2 AS was totally resistant to killing by fresh allogeneic peripheral blood lymphocytes in four hour chromium 51 release assays but induced high levels of killing in 72-hour long-term cytotoxic assays. CONCLUSION: The potential use of these interleukin-2 - secreting ovarian carcinoma cells as vaccines for women with advanced ovarian cancer will be discussed. (AM J OBSTET GYNECOL 1996;174:633-40.)" @default.
- W1975991837 created "2016-06-24" @default.
- W1975991837 creator A5010339370 @default.
- W1975991837 creator A5014125277 @default.
- W1975991837 creator A5015232515 @default.
- W1975991837 creator A5025116664 @default.
- W1975991837 creator A5049383880 @default.
- W1975991837 creator A5061182504 @default.
- W1975991837 creator A5082542753 @default.
- W1975991837 date "1996-02-01" @default.
- W1975991837 modified "2023-09-25" @default.
- W1975991837 title "Development and characterization of an interleukin-2–transduced human ovarian carcinoma tumor vaccine not expressing major histocompatibility complex molecules" @default.
- W1975991837 cites W1489777708 @default.
- W1975991837 cites W1529862692 @default.
- W1975991837 cites W1546765999 @default.
- W1975991837 cites W1630308865 @default.
- W1975991837 cites W1773381788 @default.
- W1975991837 cites W1902339425 @default.
- W1975991837 cites W1990668606 @default.
- W1975991837 cites W1998722304 @default.
- W1975991837 cites W2008564146 @default.
- W1975991837 cites W2009209888 @default.
- W1975991837 cites W2048310562 @default.
- W1975991837 cites W2061241669 @default.
- W1975991837 cites W2112352488 @default.
- W1975991837 cites W2115062537 @default.
- W1975991837 cites W2159673453 @default.
- W1975991837 cites W2322553446 @default.
- W1975991837 cites W2429127617 @default.
- W1975991837 cites W83447461 @default.
- W1975991837 doi "https://doi.org/10.1016/s0002-9378(96)70441-6" @default.
- W1975991837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8623798" @default.
- W1975991837 hasPublicationYear "1996" @default.
- W1975991837 type Work @default.
- W1975991837 sameAs 1975991837 @default.
- W1975991837 citedByCount "7" @default.
- W1975991837 crossrefType "journal-article" @default.
- W1975991837 hasAuthorship W1975991837A5010339370 @default.
- W1975991837 hasAuthorship W1975991837A5014125277 @default.
- W1975991837 hasAuthorship W1975991837A5015232515 @default.
- W1975991837 hasAuthorship W1975991837A5025116664 @default.
- W1975991837 hasAuthorship W1975991837A5049383880 @default.
- W1975991837 hasAuthorship W1975991837A5061182504 @default.
- W1975991837 hasAuthorship W1975991837A5082542753 @default.
- W1975991837 hasBestOaLocation W19759918372 @default.
- W1975991837 hasConcept C121608353 @default.
- W1975991837 hasConcept C147483822 @default.
- W1975991837 hasConcept C153911025 @default.
- W1975991837 hasConcept C154317977 @default.
- W1975991837 hasConcept C202751555 @default.
- W1975991837 hasConcept C203014093 @default.
- W1975991837 hasConcept C207936829 @default.
- W1975991837 hasConcept C2778690821 @default.
- W1975991837 hasConcept C2780427987 @default.
- W1975991837 hasConcept C3019054536 @default.
- W1975991837 hasConcept C502942594 @default.
- W1975991837 hasConcept C54355233 @default.
- W1975991837 hasConcept C55493867 @default.
- W1975991837 hasConcept C74172505 @default.
- W1975991837 hasConcept C86803240 @default.
- W1975991837 hasConcept C98119934 @default.
- W1975991837 hasConceptScore W1975991837C121608353 @default.
- W1975991837 hasConceptScore W1975991837C147483822 @default.
- W1975991837 hasConceptScore W1975991837C153911025 @default.
- W1975991837 hasConceptScore W1975991837C154317977 @default.
- W1975991837 hasConceptScore W1975991837C202751555 @default.
- W1975991837 hasConceptScore W1975991837C203014093 @default.
- W1975991837 hasConceptScore W1975991837C207936829 @default.
- W1975991837 hasConceptScore W1975991837C2778690821 @default.
- W1975991837 hasConceptScore W1975991837C2780427987 @default.
- W1975991837 hasConceptScore W1975991837C3019054536 @default.
- W1975991837 hasConceptScore W1975991837C502942594 @default.
- W1975991837 hasConceptScore W1975991837C54355233 @default.
- W1975991837 hasConceptScore W1975991837C55493867 @default.
- W1975991837 hasConceptScore W1975991837C74172505 @default.
- W1975991837 hasConceptScore W1975991837C86803240 @default.
- W1975991837 hasConceptScore W1975991837C98119934 @default.
- W1975991837 hasIssue "2" @default.
- W1975991837 hasLocation W19759918371 @default.
- W1975991837 hasLocation W19759918372 @default.
- W1975991837 hasLocation W19759918373 @default.
- W1975991837 hasOpenAccess W1975991837 @default.
- W1975991837 hasPrimaryLocation W19759918371 @default.
- W1975991837 hasRelatedWork W1989247143 @default.
- W1975991837 hasRelatedWork W1993875521 @default.
- W1975991837 hasRelatedWork W2008949385 @default.
- W1975991837 hasRelatedWork W2031508422 @default.
- W1975991837 hasRelatedWork W2041811834 @default.
- W1975991837 hasRelatedWork W2053177727 @default.
- W1975991837 hasRelatedWork W2142210143 @default.
- W1975991837 hasRelatedWork W2147236666 @default.
- W1975991837 hasRelatedWork W2488107443 @default.
- W1975991837 hasRelatedWork W4281910444 @default.
- W1975991837 hasVolume "174" @default.
- W1975991837 isParatext "false" @default.
- W1975991837 isRetracted "false" @default.
- W1975991837 magId "1975991837" @default.
- W1975991837 workType "article" @default.