FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975996526> ?p ?o ?g. }

• W1975996526 endingPage "311" @default.
• W1975996526 startingPage "306" @default.
• W1975996526 abstract "There are well-documented examples in the literature of where determining the genetic aetiology of a disorder has provided insights into important regulatory pathways and protein interactions, and, more recently, has led to improved treatment options for patients. The studies of monogenic forms of β-cell dysfunction are no exception. Naturally occurring mutations in the gene for the β-cell enzyme glucokinase (GCK) result in both hyper- and hypo-glycaemia. Over 200 mutations have been described, and careful study of the mutational mechanisms for a number of these has provided important insights into glucokinase regulation. Increased understanding of post-translational regulatory mechanisms holds the promise of novel pharmacotherapeutic options for the treatment of T2DM (Type 2 diabetes mellitus). It is well established that common genetic variation in genes involved in monogenic forms of β-cell dysfunction contributes to susceptibility to T2DM. Recent genome-wide scans for association have identified a number of novel T2DM susceptibility genes which probably influence β-cell mass and/or function. Their identification allows the investigation of the role of rare mutations in monogenic β-cell dysfunction. Current results indicate the importance of these genes in pancreatic development and suggest that mutations which result in a severe functional defect could be lethal." @default.
• W1975996526 created "2016-06-24" @default.
• W1975996526 creator A5017761772 @default.
• W1975996526 creator A5023955658 @default.
• W1975996526 creator A5035148818 @default.
• W1975996526 creator A5066704120 @default.
• W1975996526 creator A5081052392 @default.
• W1975996526 date "2008-05-21" @default.
• W1975996526 modified "2023-10-12" @default.
• W1975996526 title "Glucokinase (<i>GCK</i>) and other susceptibility genes for β-cell dysfunction: the candidate approach" @default.
• W1975996526 cites W1480222818 @default.
• W1975996526 cites W1485161311 @default.
• W1975996526 cites W1488559297 @default.
• W1975996526 cites W1965141016 @default.
• W1975996526 cites W1966650637 @default.
• W1975996526 cites W1977920296 @default.
• W1975996526 cites W1978215768 @default.
• W1975996526 cites W1988345591 @default.
• W1975996526 cites W1989273515 @default.
• W1975996526 cites W1993312496 @default.
• W1975996526 cites W2000493253 @default.
• W1975996526 cites W2004299376 @default.
• W1975996526 cites W2012515461 @default.
• W1975996526 cites W2014380041 @default.
• W1975996526 cites W2015581945 @default.
• W1975996526 cites W2033017908 @default.
• W1975996526 cites W2033757669 @default.
• W1975996526 cites W2036686913 @default.
• W1975996526 cites W2041183269 @default.
• W1975996526 cites W2049016439 @default.
• W1975996526 cites W2053192349 @default.
• W1975996526 cites W2058124421 @default.
• W1975996526 cites W2063527394 @default.
• W1975996526 cites W2063591130 @default.
• W1975996526 cites W2066536638 @default.
• W1975996526 cites W2069599670 @default.
• W1975996526 cites W2074014927 @default.
• W1975996526 cites W2081119435 @default.
• W1975996526 cites W2092102797 @default.
• W1975996526 cites W2102112706 @default.
• W1975996526 cites W2103588034 @default.
• W1975996526 cites W2111971204 @default.
• W1975996526 cites W2112040506 @default.
• W1975996526 cites W2114662094 @default.
• W1975996526 cites W2122355663 @default.
• W1975996526 cites W2128698550 @default.
• W1975996526 cites W2132041174 @default.
• W1975996526 cites W2137444779 @default.
• W1975996526 cites W2137761662 @default.
• W1975996526 cites W2137870750 @default.
• W1975996526 cites W2141698109 @default.
• W1975996526 cites W2145136028 @default.
• W1975996526 cites W2148097161 @default.
• W1975996526 cites W2155715785 @default.
• W1975996526 cites W2163747382 @default.
• W1975996526 cites W2164306929 @default.
• W1975996526 cites W2165738225 @default.
• W1975996526 cites W2168364512 @default.
• W1975996526 cites W2169174186 @default.
• W1975996526 cites W2267368291 @default.
• W1975996526 cites W2325141384 @default.
• W1975996526 cites W2330339020 @default.
• W1975996526 cites W2401183553 @default.
• W1975996526 doi "https://doi.org/10.1042/bst0360306" @default.
• W1975996526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18481947" @default.
• W1975996526 hasPublicationYear "2008" @default.
• W1975996526 type Work @default.
• W1975996526 sameAs 1975996526 @default.
• W1975996526 citedByCount "12" @default.
• W1975996526 countsByYear W19759965262018 @default.
• W1975996526 countsByYear W19759965262021 @default.
• W1975996526 countsByYear W19759965262022 @default.
• W1975996526 crossrefType "journal-article" @default.
• W1975996526 hasAuthorship W1975996526A5017761772 @default.
• W1975996526 hasAuthorship W1975996526A5023955658 @default.
• W1975996526 hasAuthorship W1975996526A5035148818 @default.
• W1975996526 hasAuthorship W1975996526A5066704120 @default.
• W1975996526 hasAuthorship W1975996526A5081052392 @default.
• W1975996526 hasConcept C104317684 @default.
• W1975996526 hasConcept C134018914 @default.
• W1975996526 hasConcept C1491633281 @default.
• W1975996526 hasConcept C2910068830 @default.
• W1975996526 hasConcept C501734568 @default.
• W1975996526 hasConcept C54355233 @default.
• W1975996526 hasConcept C555293320 @default.
• W1975996526 hasConcept C69991583 @default.
• W1975996526 hasConcept C86803240 @default.
• W1975996526 hasConcept C98335778 @default.
• W1975996526 hasConceptScore W1975996526C104317684 @default.
• W1975996526 hasConceptScore W1975996526C134018914 @default.
• W1975996526 hasConceptScore W1975996526C1491633281 @default.
• W1975996526 hasConceptScore W1975996526C2910068830 @default.
• W1975996526 hasConceptScore W1975996526C501734568 @default.
• W1975996526 hasConceptScore W1975996526C54355233 @default.
• W1975996526 hasConceptScore W1975996526C555293320 @default.
• W1975996526 hasConceptScore W1975996526C69991583 @default.
• W1975996526 hasConceptScore W1975996526C86803240 @default.
• W1975996526 hasConceptScore W1975996526C98335778 @default.

• next