Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976011051> ?p ?o ?g. }
- W1976011051 endingPage "18703" @default.
- W1976011051 startingPage "18698" @default.
- W1976011051 abstract "C-Myc is one of the most common targets of genetic alterations in human cancers. Although overexpression of c-Myc in the B cell compartment predisposes to lymphomas, secondary mutations are required for disease manifestation. In this article, we show that genetic deficiencies causing arrested B cell development and accumulation of B cell progenitors lead to accelerated lymphomagenesis in Emu c-myc transgenic mice. This result suggests that B cell progenitors are more prone than their mature counterparts to developing secondary oncogenic lesions that complement c-Myc in promoting transformation. To investigate the nature of these oncogenic lesions, we examined Emu c-myc mice deficient in mismatch repair function. We report that Msh2(-/-) Emu c-myc and Msh2(G674A/G674A) Emu c-myc mice rapidly succumb to pro-B cell stage lymphomas, indicating that Msh2-dependent mismatch repair function actively suppresses c-Myc-associated oncogenesis during early B cell development." @default.
- W1976011051 created "2016-06-24" @default.
- W1976011051 creator A5014877615 @default.
- W1976011051 creator A5027040420 @default.
- W1976011051 creator A5040092313 @default.
- W1976011051 creator A5068669060 @default.
- W1976011051 creator A5072519381 @default.
- W1976011051 date "2009-11-03" @default.
- W1976011051 modified "2023-10-01" @default.
- W1976011051 title "Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to <i>c-Myc</i> -induced lymphomas" @default.
- W1976011051 cites W1549051606 @default.
- W1976011051 cites W1675096266 @default.
- W1976011051 cites W1692796156 @default.
- W1976011051 cites W1953035097 @default.
- W1976011051 cites W1965009601 @default.
- W1976011051 cites W1968075576 @default.
- W1976011051 cites W1968083184 @default.
- W1976011051 cites W1975275032 @default.
- W1976011051 cites W1977284533 @default.
- W1976011051 cites W1977895957 @default.
- W1976011051 cites W1979718916 @default.
- W1976011051 cites W1982489194 @default.
- W1976011051 cites W1996822762 @default.
- W1976011051 cites W2000543353 @default.
- W1976011051 cites W2010674102 @default.
- W1976011051 cites W2026336857 @default.
- W1976011051 cites W2031869418 @default.
- W1976011051 cites W2032348735 @default.
- W1976011051 cites W2032972450 @default.
- W1976011051 cites W2033107164 @default.
- W1976011051 cites W2039490597 @default.
- W1976011051 cites W2042777921 @default.
- W1976011051 cites W2043798203 @default.
- W1976011051 cites W2045012725 @default.
- W1976011051 cites W2045818966 @default.
- W1976011051 cites W2046565536 @default.
- W1976011051 cites W2047889730 @default.
- W1976011051 cites W2059427680 @default.
- W1976011051 cites W2066882489 @default.
- W1976011051 cites W2068622682 @default.
- W1976011051 cites W2098497060 @default.
- W1976011051 cites W2104566573 @default.
- W1976011051 cites W2110627805 @default.
- W1976011051 cites W2112331024 @default.
- W1976011051 cites W2112881364 @default.
- W1976011051 cites W2117194146 @default.
- W1976011051 cites W2117206305 @default.
- W1976011051 cites W2121800716 @default.
- W1976011051 cites W2124295966 @default.
- W1976011051 cites W2126043518 @default.
- W1976011051 cites W2131627621 @default.
- W1976011051 cites W2140489687 @default.
- W1976011051 cites W2150608281 @default.
- W1976011051 cites W2161911875 @default.
- W1976011051 cites W2319047082 @default.
- W1976011051 cites W2334563880 @default.
- W1976011051 doi "https://doi.org/10.1073/pnas.0905965106" @default.
- W1976011051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2773990" @default.
- W1976011051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19837692" @default.
- W1976011051 hasPublicationYear "2009" @default.
- W1976011051 type Work @default.
- W1976011051 sameAs 1976011051 @default.
- W1976011051 citedByCount "14" @default.
- W1976011051 countsByYear W19760110512012 @default.
- W1976011051 countsByYear W19760110512013 @default.
- W1976011051 countsByYear W19760110512016 @default.
- W1976011051 countsByYear W19760110512018 @default.
- W1976011051 countsByYear W19760110512019 @default.
- W1976011051 countsByYear W19760110512022 @default.
- W1976011051 countsByYear W19760110512023 @default.
- W1976011051 crossrefType "journal-article" @default.
- W1976011051 hasAuthorship W1976011051A5014877615 @default.
- W1976011051 hasAuthorship W1976011051A5027040420 @default.
- W1976011051 hasAuthorship W1976011051A5040092313 @default.
- W1976011051 hasAuthorship W1976011051A5068669060 @default.
- W1976011051 hasAuthorship W1976011051A5072519381 @default.
- W1976011051 hasBestOaLocation W19760110511 @default.
- W1976011051 hasConcept C102230213 @default.
- W1976011051 hasConcept C104317684 @default.
- W1976011051 hasConcept C121608353 @default.
- W1976011051 hasConcept C134935766 @default.
- W1976011051 hasConcept C1491633281 @default.
- W1976011051 hasConcept C159654299 @default.
- W1976011051 hasConcept C201750760 @default.
- W1976011051 hasConcept C2778453870 @default.
- W1976011051 hasConcept C2779115348 @default.
- W1976011051 hasConcept C2781246680 @default.
- W1976011051 hasConcept C28328180 @default.
- W1976011051 hasConcept C31033888 @default.
- W1976011051 hasConcept C501734568 @default.
- W1976011051 hasConcept C502942594 @default.
- W1976011051 hasConcept C54355233 @default.
- W1976011051 hasConcept C552990157 @default.
- W1976011051 hasConcept C555283112 @default.
- W1976011051 hasConcept C60748783 @default.
- W1976011051 hasConcept C86803240 @default.
- W1976011051 hasConceptScore W1976011051C102230213 @default.
- W1976011051 hasConceptScore W1976011051C104317684 @default.