FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976017029> ?p ?o ?g. }

• W1976017029 endingPage "C1689" @default.
• W1976017029 startingPage "C1681" @default.
• W1976017029 abstract "The molecular mechanisms controlling β-adrenergic receptor agonist (BA)-induced skeletal muscle hypertrophy are not well known. We presently report that BA exerts a distinct muscle- and muscle fiber type-specific hypertrophy. Moreover, we have shown that pharmacologically or genetically attenuating extracellular signal-regulated kinase (ERK) signaling in muscle fibers resulted in decreases ( P < 0.05) in fast but not slow fiber type-specific reporter gene expressions in response to BA exposure in vitro and in vivo. Consistent with these data, forced expression of MAPK phosphatase 1, a nuclear protein that dephosphorylates ERK1/2, in fast-twitch skeletal muscle ablated ( P < 0.05) the hypertrophic effects of BA feeding (clenbuterol, 20 parts per million in water) in vivo. Further analysis has shown that BA-induced phosphorylation and activation of ERK occurred to a greater ( P < 0.05) extent in fast myofibers than in slow myofibers. Analysis of the basal level of ERK activity in slow and fast muscles revealed that ERK1/2 is activated to a greater extent in fast- than in slow-twitch muscles. These data indicate that ERK signaling is differentially involved in BA-induced hypertrophy in slow and fast skeletal muscles, suggesting that the increased abundance of phospho-ERK1/2 and ERK activity found in fast-twitch myofibers, compared with their slow-twitch counterparts, may account, at least in part, for the fiber type-specific hypertrophy induced by BA stimulation. These data suggest that fast myofibers are pivotal in the adaptation of muscle to environmental cues and that the mechanism underlying this change is partially mediated by the MAPK signaling cascade." @default.
• W1976017029 created "2016-06-24" @default.
• W1976017029 creator A5015584667 @default.
• W1976017029 creator A5046531172 @default.
• W1976017029 creator A5049584451 @default.
• W1976017029 creator A5067776427 @default.
• W1976017029 creator A5075016562 @default.
• W1976017029 creator A5079887522 @default.
• W1976017029 date "2007-05-01" @default.
• W1976017029 modified "2023-09-26" @default.
• W1976017029 title "Extracellular signal-regulated kinase pathway is differentially involved in β-agonist-induced hypertrophy in slow and fast muscles" @default.
• W1976017029 cites W11492256 @default.
• W1976017029 cites W1526273052 @default.
• W1976017029 cites W1530473805 @default.
• W1976017029 cites W1543291357 @default.
• W1976017029 cites W1586159393 @default.
• W1976017029 cites W1633206935 @default.
• W1976017029 cites W1769585641 @default.
• W1976017029 cites W1770040190 @default.
• W1976017029 cites W1833512305 @default.
• W1976017029 cites W1941910566 @default.
• W1976017029 cites W1965044262 @default.
• W1976017029 cites W1969927905 @default.
• W1976017029 cites W1971857747 @default.
• W1976017029 cites W1973144987 @default.
• W1976017029 cites W1975217943 @default.
• W1976017029 cites W1975358464 @default.
• W1976017029 cites W1995357570 @default.
• W1976017029 cites W2001610575 @default.
• W1976017029 cites W2005101201 @default.
• W1976017029 cites W2011173742 @default.
• W1976017029 cites W2016125879 @default.
• W1976017029 cites W2017429680 @default.
• W1976017029 cites W2020760006 @default.
• W1976017029 cites W2021669986 @default.
• W1976017029 cites W2022576341 @default.
• W1976017029 cites W2033797333 @default.
• W1976017029 cites W2062892401 @default.
• W1976017029 cites W2067680253 @default.
• W1976017029 cites W2069257264 @default.
• W1976017029 cites W2082889823 @default.
• W1976017029 cites W2086656837 @default.
• W1976017029 cites W2091366475 @default.
• W1976017029 cites W2109616052 @default.
• W1976017029 cites W2110527130 @default.
• W1976017029 cites W2124496590 @default.
• W1976017029 cites W2151312020 @default.
• W1976017029 cites W2155605721 @default.
• W1976017029 cites W2166416342 @default.
• W1976017029 cites W2166748873 @default.
• W1976017029 cites W2168871241 @default.
• W1976017029 cites W2227857135 @default.
• W1976017029 cites W2335484570 @default.
• W1976017029 cites W2415143274 @default.
• W1976017029 cites W2416071177 @default.
• W1976017029 cites W2792659630 @default.
• W1976017029 doi "https://doi.org/10.1152/ajpcell.00466.2006" @default.
• W1976017029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17151143" @default.
• W1976017029 hasPublicationYear "2007" @default.
• W1976017029 type Work @default.
• W1976017029 sameAs 1976017029 @default.
• W1976017029 citedByCount "67" @default.
• W1976017029 countsByYear W19760170292012 @default.
• W1976017029 countsByYear W19760170292013 @default.
• W1976017029 countsByYear W19760170292014 @default.
• W1976017029 countsByYear W19760170292015 @default.
• W1976017029 countsByYear W19760170292016 @default.
• W1976017029 countsByYear W19760170292017 @default.
• W1976017029 countsByYear W19760170292018 @default.
• W1976017029 countsByYear W19760170292019 @default.
• W1976017029 countsByYear W19760170292020 @default.
• W1976017029 countsByYear W19760170292021 @default.
• W1976017029 countsByYear W19760170292022 @default.
• W1976017029 crossrefType "journal-article" @default.
• W1976017029 hasAuthorship W1976017029A5015584667 @default.
• W1976017029 hasAuthorship W1976017029A5046531172 @default.
• W1976017029 hasAuthorship W1976017029A5049584451 @default.
• W1976017029 hasAuthorship W1976017029A5067776427 @default.
• W1976017029 hasAuthorship W1976017029A5075016562 @default.
• W1976017029 hasAuthorship W1976017029A5079887522 @default.
• W1976017029 hasConcept C11960822 @default.
• W1976017029 hasConcept C126322002 @default.
• W1976017029 hasConcept C134018914 @default.
• W1976017029 hasConcept C167414201 @default.
• W1976017029 hasConcept C170493617 @default.
• W1976017029 hasConcept C178666793 @default.
• W1976017029 hasConcept C184235292 @default.
• W1976017029 hasConcept C185592680 @default.
• W1976017029 hasConcept C207200792 @default.
• W1976017029 hasConcept C2776327530 @default.
• W1976017029 hasConcept C2778938600 @default.
• W1976017029 hasConcept C2779959927 @default.
• W1976017029 hasConcept C28406088 @default.
• W1976017029 hasConcept C55493867 @default.
• W1976017029 hasConcept C57074206 @default.
• W1976017029 hasConcept C62478195 @default.
• W1976017029 hasConcept C71924100 @default.
• W1976017029 hasConcept C86803240 @default.

• next